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    Childhood-onset schizophrenia. A double-blind clozapine-haloperidol comparison

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    Authors
    Kumra, Sanjiv
    Frazier, Jean A.
    Jacobsen, Leslie K.
    McKenna, Kathleen
    Gordon, Charles T.
    Lenane, Marge C.
    Hamburger, Susan D.
    Smith, A. K.
    Albus, K. E.
    Alaghband-Rad, Javad
    Rapoport, Judith L.
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    UMass Chan Affiliations
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    1996-12-01
    Keywords
    Adolescent
    Age Factors
    Age of Onset
    Child
    Child, Preschool
    Clozapine
    Double-Blind Method
    Drug Administration Schedule
    Haloperidol
    Humans
    Neutropenia
    Psychiatric Status Rating Scales
    Schizophrenia, Childhood
    Seizures
    Severity of Illness Index
    Treatment Outcome
    Psychiatry
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    Link to Full Text
    http://archpsyc.ama-assn.org/cgi/reprint/53/12/1090
    Abstract
    BACKGROUND: Childhood-onset schizophrenia is a rare but severe form of the disorder that is often treatment-refractory. In this study, the efficacy and adverse effects of clozapine and haloperidol were compared for children and adolescents with early-onset schizophrenia. METHODS: Twenty-one patients (mean [+/-SD] age, 14.0 +/- 2.3 years) with onset of Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition-defined schizophrenia that began by age 12 years and who had been nonresponsive to typical neuroleptics participated in the study. Patients were randomized to a 6-week double-blind parallel comparison of clozapine (mean [+/-SD] final dose, 176 +/- 149 mg/d), or haloperidol, (16 +/- 8 mg/d). RESULTS: Clozapine was superior to haloperidol on all measures of psychosis (P = .04-.002). Positive and negative symptoms of schizophrenia improved. However, neutropenia and seizures were major concerns. To date, one third of the group has discontinued using clozapine. CONCLUSIONS: Clozapine has striking superiority for positive and negative symptoms in treatment-refractory childhood-onset schizophrenia. However, due to possibly increased toxic effects in this pediatric population, close monitoring for adverse events is essential.
    Source
    Arch Gen Psychiatry. 1996 Dec;53(12):1090-7.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/45911
    PubMed ID
    8956674
    Related Resources
    Link to Article in PubMed
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    UMass Chan Faculty and Researcher Publications

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