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dc.contributor.authorRenshaw, Perry F.
dc.contributor.authorLafer, Beny
dc.contributor.authorBabb, Suzann M.
dc.contributor.authorFava, Maurizio
dc.contributor.authorStoll, Andrew L.
dc.contributor.authorChristensen, James D.
dc.contributor.authorMoore, Constance M.
dc.contributor.authorYurgelun-Todd, Deborah A.
dc.contributor.authorBonello, Christina M.
dc.contributor.authorPillay, Srinivasan S.
dc.contributor.authorRothschild, Anthony J.
dc.contributor.authorNierenberg, Andrew A.
dc.contributor.authorRosenbaum, Jerrold F.
dc.contributor.authorCohen, Bruce M.
dc.date2022-08-11T08:10:28.000
dc.date.accessioned2022-08-23T17:09:56Z
dc.date.available2022-08-23T17:09:56Z
dc.date.issued1997-04-15
dc.date.submitted2010-05-05
dc.identifier.citationBiol Psychiatry. 1997 Apr 15;41(8):837-43. <a href="http://dx.doi.org/10.1016/S0006-3223(96)00256-9">Link to article on publisher's site</a>
dc.identifier.issn0006-3223 (Linking)
dc.identifier.doi10.1016/S0006-3223(96)00256-9
dc.identifier.pmid9099409
dc.identifier.urihttp://hdl.handle.net/20.500.14038/45934
dc.description.abstractWe have investigated proton magnetic resonance spectra of the basal ganglia in 41 medication-free outpatients with major depression, prior to starting an 8-week standardized trial of open-label fluoxetine, and 22 matched comparison subjects. Upon completing the trial, depressed subjects were classified as treatment responders (n = 18) or nonresponders (n = 23), based on changes in the Hamilton Depression Rating Scale. Depressed subjects had a lower area ratio of the choline resonance to the creatine resonance (Cho/Cr) than comparison subjects. This statistically significant difference between the depressed subjects and comparison subjects was more pronounced in the treatment responders than in the nonresponders. There were no differences in the relative volumes of gray matter or white matter in the voxel used for proton spectroscopy in depressed subjects relative to comparison subjects. These results are consistent with an alteration in the metabolism of cytosolic choline compounds in the basal ganglia of depressed subjects and, in particular, those who are responsive to fluoxetine.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=9099409&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/S0006-3223(96)00256-9
dc.subjectAdult
dc.subjectAntidepressive Agents, Second-Generation
dc.subjectBasal Ganglia
dc.subjectCholine
dc.subjectDepression
dc.subjectFemale
dc.subjectFluoxetine
dc.subjectHumans
dc.subjectImage Interpretation, Computer-Assisted
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectPsychiatric Status Rating Scales
dc.subjectPsychiatry
dc.titleBasal ganglia choline levels in depression and response to fluoxetine treatment: an in vivo proton magnetic resonance spectroscopy study
dc.typeJournal Article
dc.source.journaltitleBiological psychiatry
dc.source.volume41
dc.source.issue8
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/46
dc.identifier.contextkey1299393
html.description.abstract<p>We have investigated proton magnetic resonance spectra of the basal ganglia in 41 medication-free outpatients with major depression, prior to starting an 8-week standardized trial of open-label fluoxetine, and 22 matched comparison subjects. Upon completing the trial, depressed subjects were classified as treatment responders (n = 18) or nonresponders (n = 23), based on changes in the Hamilton Depression Rating Scale. Depressed subjects had a lower area ratio of the choline resonance to the creatine resonance (Cho/Cr) than comparison subjects. This statistically significant difference between the depressed subjects and comparison subjects was more pronounced in the treatment responders than in the nonresponders. There were no differences in the relative volumes of gray matter or white matter in the voxel used for proton spectroscopy in depressed subjects relative to comparison subjects. These results are consistent with an alteration in the metabolism of cytosolic choline compounds in the basal ganglia of depressed subjects and, in particular, those who are responsive to fluoxetine.</p>
dc.identifier.submissionpathpsych_pp/46
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages837-43


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