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    High-resolution fMRI mapping of ocular dominance layers in cat lateral geniculate nucleus

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    Authors
    Zhang, Nanyin
    Zhu, Xiao-Hong
    Zhang, Yi
    Park, Jae-keun
    Chen, Wei
    UMass Chan Affiliations
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    2010-05-01
    Keywords
    Animals
    Artifacts
    Blood Volume
    Cats
    Cerebrovascular Circulation
    Functional Laterality
    Geniculate Bodies
    Magnetic Resonance Imaging
    Oxygen
    Photic Stimulation
    Reproducibility of Results
    *Signal Processing, Computer-Assisted
    Visual Perception
    Psychiatry
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838974/pdf/nihms175404.pdf
    Abstract
    In this work, we exploited the superior capability of high-resolution functional magnetic resonance imaging (fMRI) for functional mapping of ocular dominance layer (ODL) in the cat lateral geniculate nucleus (LGN). The stimulus-evoked neuronal activities in the LGN ODLs associated with contralateral- and ipsilateral-eye visual inputs were successfully differentiated and mapped using both blood-oxygenation-level dependent (BOLD)-weighted and cerebral blood volume (CBV)-weighted fMRI methods. The morphology of mapped LGN ODLs was in remarkable consistency with histology findings in terms of ODL shape, orientation, thickness and eye-dominance. Compared with the BOLD signal, the CBV signal provides higher reproducibility and better spatial resolvability for function mapping of LGN because of improved contrast-to-noise ratio and point-spread function. The capability of fMRI for non-invasively imaging the functional sub-units of ODL in a small LGN overcomes the limitation of conventional neural-recording approach, and it opens a new opportunity for studying critical roles of LGN in brain function and dysfunction at the fine scale of ocular dominance layer.
    Source
    Neuroimage. 2010 May 1;50(4):1456-63. Epub 2010 Jan 28. Link to article on publisher's site
    DOI
    10.1016/j.neuroimage.2010.01.053
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/45974
    PubMed ID
    20114078
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neuroimage.2010.01.053
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