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dc.contributor.authorBelanoff, Joseph K.
dc.contributor.authorRothschild, Anthony J.
dc.contributor.authorCassidy, Frederick
dc.contributor.authorDeBattista, Charles
dc.contributor.authorEmile Baulieu, Etienne
dc.contributor.authorSchold, Clifford
dc.contributor.authorSchatzberg, Alan F.
dc.date2022-08-11T08:10:28.000
dc.date.accessioned2022-08-23T17:10:21Z
dc.date.available2022-08-23T17:10:21Z
dc.date.issued2002-09-21
dc.date.submitted2010-05-05
dc.identifier.citationBiol Psychiatry. 2002 Sep 1;52(5):386-92.
dc.identifier.issn0006-3223 (Linking)
dc.identifier.pmid12242054
dc.identifier.urihttp://hdl.handle.net/20.500.14038/46030
dc.description.abstractBACKGROUND: The rationale for treating patients with psychotic major depression (PMD) with glucocorticosteroid receptor (GR) antagonists is explained. METHODS: Thirty patients with PMD, with Hamilton Rating Scale for Depression (HAMD-21) scores of 18 or greater, were assigned in an open label trial to receive 50 mg, 600 mg, or 1200 mg of mifepristone for 7 days. RESULTS: All the subjects completed the protocol; there were no dropouts. Side effects were mild and sporadic. Of 19 subjects in the combined 600- and 1200-mg group, 13 had a 30% or greater decline in their Brief Psychiatric Rating Scale (BPRS) scores, compared with 4 of 11 in the 50-mg group. In the 600- and 1200-mg group, 12 of 19 subjects showed a 50% decline in the BPRS positive symptom subscale, a more sensitive index for the symptoms seen in PMD, compared with 3 of 11 in the 50-mg group; 8 of 19 subjects in the 600- and 1200-mg group had a 50% decline in the HAMD-21, compared with 2 of 11 in the 50-mg group. CONCLUSIONS: These results suggest that short term use of GR antagonists may be effective in the treatment of psychotic major depression and that further blinded studies are warranted.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=12242054&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/S0006-3223(02)01432-4
dc.subjectAdult
dc.subjectAged
dc.subjectDepressive Disorder, Major
dc.subjectDose-Response Relationship, Drug
dc.subjectFemale
dc.subjectHormone Antagonists
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMifepristone
dc.subjectPsychiatric Status Rating Scales
dc.subjectTreatment Outcome
dc.subjectPsychiatry
dc.titleAn open label trial of C-1073 (mifepristone) for psychotic major depression
dc.typeJournal Article
dc.source.journaltitleBiological psychiatry
dc.source.volume52
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/56
dc.identifier.contextkey1299403
html.description.abstract<p>BACKGROUND: The rationale for treating patients with psychotic major depression (PMD) with glucocorticosteroid receptor (GR) antagonists is explained.</p> <p>METHODS: Thirty patients with PMD, with Hamilton Rating Scale for Depression (HAMD-21) scores of 18 or greater, were assigned in an open label trial to receive 50 mg, 600 mg, or 1200 mg of mifepristone for 7 days.</p> <p>RESULTS: All the subjects completed the protocol; there were no dropouts. Side effects were mild and sporadic. Of 19 subjects in the combined 600- and 1200-mg group, 13 had a 30% or greater decline in their Brief Psychiatric Rating Scale (BPRS) scores, compared with 4 of 11 in the 50-mg group. In the 600- and 1200-mg group, 12 of 19 subjects showed a 50% decline in the BPRS positive symptom subscale, a more sensitive index for the symptoms seen in PMD, compared with 3 of 11 in the 50-mg group; 8 of 19 subjects in the 600- and 1200-mg group had a 50% decline in the HAMD-21, compared with 2 of 11 in the 50-mg group.</p> <p>CONCLUSIONS: These results suggest that short term use of GR antagonists may be effective in the treatment of psychotic major depression and that further blinded studies are warranted.</p>
dc.identifier.submissionpathpsych_pp/56
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages386-92


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