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Authors
Brown, Timothy T.Kuperman, Joshua M.
Chung, Yoonho
Erhart, Matthew
McCabe, Connor
Hagler, Donald J. Jr.
Venkatraman, Vijay K.
Akshoomoff, Natacha
Amaral, David G.
Bloss, Cinnamon S.
Casey, B. J.
Chang, Linda
Ernst, Thomas M.
Frazier, Jean A.
Gruen, Jeffrey R.
Kaufmann, Walter E.
Kenet, Tal
Kennedy, David N.
Murray, Sarah S.
Sowell, Elizabeth R.
Jernigan, Terry L.
Dale, Anders
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2012-09-25Keywords
Magnetic Resonance ImagingNeuroimaging
Brain
Neuroanatomy
Nervous System
Neuroscience and Neurobiology
Psychiatry
Psychiatry and Psychology
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Show full item recordAbstract
Structural MRI allows unparalleled in vivo study of the anatomy of the developing human brain. For more than two decades, MRI research has revealed many new aspects of this multifaceted maturation process, significantly augmenting scientific knowledge gathered from postmortem studies. Postnatal brain development is notably protracted and involves considerable changes in cerebral cortical, subcortical, and cerebellar structures, as well as significant architectural changes in white matter fiber tracts (see [12]). Although much work has described isolated features of neuroanatomical development, it remains a critical challenge to characterize the multidimensional nature of brain anatomy, capturing different phases of development among individuals. Capitalizing on key advances in multisite, multimodal MRI, and using cross-validated nonlinear modeling, we demonstrate that developmental brain phase can be assessed with much greater precision than has been possible using other biological measures, accounting for more than 92% of the variance in age. Further, our composite metric of morphology, diffusivity, and signal intensity shows that the average difference in phase among children of the same age is only about 1 year, revealing for the first time a latent phenotype in the human brain for which maturation timing is tightly controlled.Source
Curr Biol. 2012 Sep 25;22(18):1693-8. doi: 10.1016/j.cub.2012.07.002. Epub 2012 Aug 16. Link to article on publisher's siteDOI
10.1016/j.cub.2012.07.002Permanent Link to this Item
http://hdl.handle.net/20.500.14038/46036PubMed ID
22902750Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.cub.2012.07.002