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    Brief depressive symptoms in patients with bipolar disorder: analysis of long-term self-reported data

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    Authors
    Bauer, Michael
    Glenn, Tasha
    Keil, Michael
    Bauer, Rita
    Marsh, Wendy K.
    Grof, Paul
    Alda, Martin
    Sagduyu, Kemal
    Murray, Greg
    Quiroz, Danilo
    Baethge, Christopher
    Whybrow, Peter C.
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    UMass Chan Affiliations
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    2012-11-01
    Keywords
    Bipolar Disorder
    Depression
    UMCCTS funding
    Mental and Social Health
    Psychiatry
    Psychiatry and Psychology
    
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    Link to Full Text
    http://dx.doi.org/10.1177/0004867412452017
    Abstract
    OBJECTIVE: Most patients with bipolar disorder experience depressive symptoms outside of an episode of depression as defined by DSM-IV criteria. This study explores the frequency of brief depressive episodes, lasting 1 to 4 days, using daily self-reported mood ratings. METHOD: Mood ratings were obtained from 448 patients (281 bipolar I, 167 bipolar II) using ChronoRecord software (91,786 total days). Episodes of depression and days of depression outside of episodes were determined. The intensity of depressive symptoms (mild versus moderate to severe) was compared. RESULTS: Using the DSM-IV length criteria, 61% of all depressive days occurred outside of a depressed episode. Decreasing the minimum length criterion to 2 days, both the number of patients experiencing a depressed episode (128 to 317) and the mean percent of days spent in a depressed episode by each patient (7.9% to 17.8.%) increased by about 2(1/2) times, and 34.3% of depressed days remained outside of an episode. Depending on the episode length, the proportion of days within an episode with severe symptoms varied from 1/3 to 1/4 for episodes lasting from 14 to 2 days, and 1/4 for single-day episodes. There was no significant difference in the frequency of brief depressive episodes between bipolar I and II disorders. For all episode lengths, patients taking antidepressants spent 4% more days within an episode and 6% more days with depressive symptoms outside of an episode than those not taking antidepressants. CONCLUSION: Brief depressive episodes lasting 1 to 4 days occur frequently in bipolar disorder and do not distinguish between bipolar I and II disorders. Symptoms of moderate to severe intensity occur on 1/4 to 1/3 of the days in brief depressive episodes. This study did not address brief depression in those without bipolar disorder. Patients taking antidepressants experienced more brief depressive episodes. Controlled trials are needed to assess the impact of antidepressants on subsyndromal depressive symptoms.
    Source
    Aust N Z J Psychiatry. 2012 Nov;46(11):1068-78. doi: 10.1177/0004867412452017. Link to article on publisher's site
    DOI
    10.1177/0004867412452017
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46072
    PubMed ID
    22734088
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1177/0004867412452017
    Scopus Count
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    UMass Chan Faculty and Researcher Publications
    UMass Center for Clinical and Translational Science Supported Publications

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