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dc.contributor.authorBauer, Michael
dc.contributor.authorGlenn, Tasha
dc.contributor.authorGrof, Paul
dc.contributor.authorRasgon, Natalie L.
dc.contributor.authorMarsh, Wendy K.
dc.contributor.authorSagduyu, Kemal
dc.contributor.authorAlda, Martin
dc.contributor.authorLewitzka, Ute
dc.contributor.authorSchmid, Rita
dc.contributor.authorWhybrow, Peter C.
dc.date2022-08-11T08:10:28.000
dc.date.accessioned2022-08-23T17:10:34Z
dc.date.available2022-08-23T17:10:34Z
dc.date.issued2009-03-01
dc.date.submitted2013-02-25
dc.identifier.citationBauer M, Glenn T, Grof P, Rasgon NL, Marsh W, Sagduyu K, Alda M, Lewitzka U, Schmid R, Whybrow PC: Relationship between adjunctive medications for anxiety and time spent ill in patients with bipolar disorder. International Journal of Psychiatry in Clinical Practice. Mar 2009; 13(1): 70-77. doi:10.1080/13651500802450514
dc.identifier.doi10.1080/13651500802450514
dc.identifier.urihttp://hdl.handle.net/20.500.14038/46074
dc.description.abstractObjective. Many patients with bipolar disorder take adjunctive medications for anxiety. Using naturalistic data, we investigated the relationship between the use of adjunctive anxiolytics and the time spent in episodes or with subsyndromal mood symptoms. Methods. This was a post-hoc analysis of 310 patients with bipolar disorder who previously recorded mood and medications daily for 5 months using ChronoRecord software. One hundred patients were taking adjunctive anxiolytics for at least 50% of days; 210 were not. Of the 100 patients, 73 were taking a benzodiazepine. All patients taking anxiolytics were also receiving treatments for bipolar disorder. Results. Patients with bipolar disorder who were taking adjunctive medications for anxiety spent more time ill. Comparing patients who were taking or not taking anxiolytics, the mean days spent either in any episode or with subsyndromal symptoms was 45.6 vs. 29.6%, respectively (P<0.001), the mean days in any episode was 17.1 vs. 9.2%, respectively (P=0.016), and the mean days with subsyndromal depression was 26.4 vs. 16.2%, respectively (P=0.004). Conclusion. While this methodology cannot determine causality, these findings highlight the need for controlled studies of the long-term impact of adjunctive medications for anxiety on mood symptoms in patients being treated for bipolar disorder.
dc.language.isoen_US
dc.relation.urlhttp://dx.doi.org/10.1080/13651500802450514
dc.subjectBipolar Disorder
dc.subjectAnxiety Disorders
dc.subjectAnti-Anxiety Agents
dc.subjectMental and Social Health
dc.subjectPsychiatry
dc.subjectPsychiatry and Psychology
dc.titleRelationship between adjunctive medications for anxiety and time spent ill in patients with bipolar disorder
dc.typeJournal Article
dc.source.journaltitleInternational Journal of Psychiatry in Clinical Practice
dc.source.volume13
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/603
dc.identifier.contextkey3778544
html.description.abstract<p><em>Objective.</em> Many patients with bipolar disorder take adjunctive medications for anxiety. Using naturalistic data, we investigated the relationship between the use of adjunctive anxiolytics and the time spent in episodes or with subsyndromal mood symptoms.</p> <p><em>Methods.</em> This was a post-hoc analysis of 310 patients with bipolar disorder who previously recorded mood and medications daily for 5 months using ChronoRecord software. One hundred patients were taking adjunctive anxiolytics for at least 50% of days; 210 were not. Of the 100 patients, 73 were taking a benzodiazepine. All patients taking anxiolytics were also receiving treatments for bipolar disorder.</p> <p><em>Results.</em> Patients with bipolar disorder who were taking adjunctive medications for anxiety spent more time ill. Comparing patients who were taking or not taking anxiolytics, the mean days spent either in any episode or with subsyndromal symptoms was 45.6 vs. 29.6%, respectively (<em>P</em><0.001), the mean days in any episode was 17.1 vs. 9.2%, respectively (<em>P</em>=0.016), and the mean days with subsyndromal depression was 26.4 vs. 16.2%, respectively (<em>P</em>=0.004).</p> <p><em>Conclusion.</em> While this methodology cannot determine causality, these findings highlight the need for controlled studies of the long-term impact of adjunctive medications for anxiety on mood symptoms in patients being treated for bipolar disorder.<br /><br /></p>
dc.identifier.submissionpathpsych_pp/603
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages70-77


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