Multi-modal approach for investigating brain and behavior changes in an animal model of traumatic brain injury
AuthorsHeffernan, Meghan E.
Sicard, Kenneth M.
Bratane, Bernt T.
King, Jean A.
Sikoglu, Elif M.
Document TypeAccepted Manuscript
Magnetic Resonance Imaging
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Nervous System Diseases
Neuroscience and Neurobiology
Psychiatry and Psychology
MetadataShow full item record
AbstractUtilization of novel approaches in imaging modalities are needed for enhancing diagnostic and therapeutic outcomes of persons suffering a traumatic brain injury (TBI). This study explored the feasibility of using functional magnetic resonance imaging (fMRI) in conjunction with behavioral measures to target dynamic changes in specific neural circuitries in an animal model of traumatic brain injury. Wistar rats were randomly assigned to one of two groups (traumatic brain injury / sham operation). TBI rats were subjected to the closed head injury (CHI) model. Any observable motor deficits and cognitive deficits associated with the injury were measured using Beam Walk and Morris Water Maze tests, respectively. fMRI was performed to assess the underlying post-traumatic cerebral anatomy and function in acute (24 hours after the injury) and chronic (7 and 21 days after the injury) phases. Beam Walk test results detected no significant differences in motor deficits between groups. Morris Water Maze test indicated that cognitive deficits persisted for the first week following injury and to a large extent, recovered thereafter. Resting state functional connectivity (rsFC) analysis detected initially diminished connectivity between cortical areas involved in cognition for the TBI group; however the connectivity patterns normalized at one week and remained so at three weeks post-injury timepoint. Taken together, we have demonstrated an objective in vivo marker for mapping functional brain changes correlated with injury-associated cognitive behavior deficits and offer an animal model for testing potential therapeutic interventions options.
SourceJ Neurotrauma. 2013 Jan 7. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/46082
Related ResourcesLink to Article in PubMed
RightsThis is a copy of an article published in the Journal of Neurotrauma © 2013 copyright Mary Ann Liebert, Inc.; Journal of Neurotrauma is available online at: http://online.liebertpub.com. Author postprint posted as allowed by the publisher's self-archiving policy at http://www.liebertpub.com/nv/resources-tools/self-archiving-policy/51/.