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    GABAergic neuroactive steroids and resting-state functional connectivity in postpartum depression: a preliminary study

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    Authors
    Deligiannidis, Kristina M.
    Sikoglu, Elif M.
    Shaffer, Scott A.
    Frederick, Blaise
    Svenson, Abby E.
    Kopoyan, Andre
    Kosma, Chelsea A.
    Rothschild, Anthony J.
    Moore, Constance M.
    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    2013-06-01
    Keywords
    Depression, Postpartum
    Neurotransmitter Agents
    GABA Agents
    UMCCTS funding
    Mental and Social Health
    Mental Disorders
    Neuroscience and Neurobiology
    Psychiatry
    Psychiatry and Psychology
    Women's Health
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983790/
    Abstract
    Postpartum depression (PPD) affects up to 1 in 8 women. The early postpartum period is characterized by a downward physiological shift from relatively elevated levels of sex steroids during pregnancy to diminished levels after parturition. Sex steroids influence functional brain connectivity in healthy non-puerperal subjects. This study tests the hypothesis that PPD is associated with attenuation of resting-state functional connectivity (rs-fc) within corticolimbic regions implicated in depression and alterations in neuroactive steroid concentrations as compared to healthy postpartum women. Subjects (n = 32) were prospectively evaluated during pregnancy and in the postpartum with repeated plasma neuroactive steroid measurements and mood and psychosocial assessments. Healthy comparison subjects (HCS) and medication-free subjects with unipolar PPD (PPD) were examined using functional magnetic resonance imaging (fMRI) within 9 weeks of delivery. We performed rs-fc analysis with seeds placed in the anterior cingulate cortex (ACC), and bilateral amygdala (AMYG), hippocampi (HIPP) and dorsolateral prefrontal cortices (DLPFCs). Postpartum rs-fc and perinatal neuroactive steroid plasma concentrations, quantified by liquid chromatography/mass spectrometry, were compared between groups. PPD subjects showed attenuation of connectivity for each of the tested regions (i.e. ACC, AMYG, HIPP and DLPFC) and between corticocortical and corticolimbic regions vs. HCS. Perinatal concentrations of pregnanolone, allopregnanolone and pregnenolone were not different between groups. This is the first report of a disruption in the rs-fc patterns in medication-free subjects with PPD. This disruption may contribute to the development of PPD, at a time of falling neuroactive steroid concentrations.
    Source

    Deligiannidis KM, Sikoglu EM, Shaffer SA, Frederick B, Svenson AE, Kopoyan A, Kosma CA, Rothschild AJ, Moore CM. GABAergic neuroactive steroids and resting-state functional connectivity in postpartum depression: a preliminary study. J Psychiatr Res. 2013 Jun;47(6):816-28. doi:10.1016/j.jpsychires.2013.02.010.

    DOI
    10.1016/j.jpsychires.2013.02.010
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46092
    PubMed ID
    23499388
    Related Resources

    Link to article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jpsychires.2013.02.010
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