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    Prolactin serum levels correlate with inflammatory status in drug-naive first-episode schizophrenia

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    Authors
    Song, Xueqin
    Fan, Xiaoduo
    Zhang, Jianjiang
    Zheng, Hui
    Li, Xue
    Pang, Lijuan
    Chen, Xumei
    Zhang, Wei
    Harrington, Amy
    Ziedonis, Douglas M.
    Lv, Luxian
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    UMass Chan Affiliations
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    2014-09-01
    Keywords
    Immunopathology
    Mental and Social Health
    Mental Disorders
    Psychiatry
    Psychiatry and Psychology
    
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    Link to Full Text
    http://dx/doi.org/10.3109/15622975.2014.922699
    Abstract
    Objectives. The present study was to examine the relationship between serum levels of prolactin and the inflammatory status in drug-naive, first-episode schizophrenia patients with normal weight. Methods. Patients with normal weight, drug-naive, first-episode schizophrenia and healthy controls were enrolled in the study. Serum levels of prolactin (PRL) were measured using electrical chemiluminescence immunoassay. Serum levels of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were examined using enzyme-linked immunosorbent assay (ELISA). Results. Sixty patients with normal weight, drug-naive, first-episode schizophrenia and 60 healthy controls were enrolled. The schizophrenia group had higher serum levels of PRL, IL-1beta, IL-6 and TNF-alpha compared with the control group. There was a gender difference of hyperprolactinemia in schizophrenia group. There were positive relationships between serum levels of PRL and serum levels of IL-1beta, IL-6 and TNF-alpha within the schizophrenia group. Within the schizophrenia group, TNF-alpha was the strongest predictor among the three cytokines for serum levels of prolactin after controlling for gender, age, education, smoking status and disease duration. Conclusions. Patients with normal weight, drug-naive, first-episode schizophrenia present elevated serum levels of PRL, which might be related to the up-regulated inflammatory status in this patient population.
    Source
    World J Biol Psychiatry. 2014 Sep;15(7):546-52. doi: 10.3109/15622975.2014.922699 Link to article on publisher's site
    DOI
    10.3109/15622975.2014.922699
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46126
    PubMed ID
    24959913
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.3109/15622975.2014.922699
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