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dc.contributor.authorSong, Xueqin
dc.contributor.authorFan, Xiaoduo
dc.contributor.authorZhang, Jianjiang
dc.contributor.authorZheng, Hui
dc.contributor.authorLi, Xue
dc.contributor.authorPang, Lijuan
dc.contributor.authorChen, Xumei
dc.contributor.authorZhang, Wei
dc.contributor.authorHarrington, Amy
dc.contributor.authorZiedonis, Douglas M.
dc.contributor.authorLv, Luxian
dc.date2022-08-11T08:10:29.000
dc.date.accessioned2022-08-23T17:10:48Z
dc.date.available2022-08-23T17:10:48Z
dc.date.issued2014-09-01
dc.date.submitted2014-09-16
dc.identifier.citationWorld J Biol Psychiatry. 2014 Sep;15(7):546-52. doi: 10.3109/15622975.2014.922699 <a href="http://dx.doi.org/10.3109/15622975.2014.922699">Link to article on publisher's site</a>
dc.identifier.issn1562-2975 (Linking)
dc.identifier.doi10.3109/15622975.2014.922699
dc.identifier.pmid24959913
dc.identifier.urihttp://hdl.handle.net/20.500.14038/46126
dc.description.abstractObjectives. The present study was to examine the relationship between serum levels of prolactin and the inflammatory status in drug-naive, first-episode schizophrenia patients with normal weight. Methods. Patients with normal weight, drug-naive, first-episode schizophrenia and healthy controls were enrolled in the study. Serum levels of prolactin (PRL) were measured using electrical chemiluminescence immunoassay. Serum levels of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were examined using enzyme-linked immunosorbent assay (ELISA). Results. Sixty patients with normal weight, drug-naive, first-episode schizophrenia and 60 healthy controls were enrolled. The schizophrenia group had higher serum levels of PRL, IL-1beta, IL-6 and TNF-alpha compared with the control group. There was a gender difference of hyperprolactinemia in schizophrenia group. There were positive relationships between serum levels of PRL and serum levels of IL-1beta, IL-6 and TNF-alpha within the schizophrenia group. Within the schizophrenia group, TNF-alpha was the strongest predictor among the three cytokines for serum levels of prolactin after controlling for gender, age, education, smoking status and disease duration. Conclusions. Patients with normal weight, drug-naive, first-episode schizophrenia present elevated serum levels of PRL, which might be related to the up-regulated inflammatory status in this patient population.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24959913&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx/doi.org/10.3109/15622975.2014.922699
dc.subjectImmunopathology
dc.subjectMental and Social Health
dc.subjectMental Disorders
dc.subjectPsychiatry
dc.subjectPsychiatry and Psychology
dc.titleProlactin serum levels correlate with inflammatory status in drug-naive first-episode schizophrenia
dc.typeJournal Article
dc.source.journaltitleThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
dc.source.volume15
dc.source.issue7
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/662
dc.identifier.contextkey6123874
html.description.abstract<p>Objectives. The present study was to examine the relationship between serum levels of prolactin and the inflammatory status in drug-naive, first-episode schizophrenia patients with normal weight.</p> <p>Methods. Patients with normal weight, drug-naive, first-episode schizophrenia and healthy controls were enrolled in the study. Serum levels of prolactin (PRL) were measured using electrical chemiluminescence immunoassay. Serum levels of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were examined using enzyme-linked immunosorbent assay (ELISA).</p> <p>Results. Sixty patients with normal weight, drug-naive, first-episode schizophrenia and 60 healthy controls were enrolled. The schizophrenia group had higher serum levels of PRL, IL-1beta, IL-6 and TNF-alpha compared with the control group. There was a gender difference of hyperprolactinemia in schizophrenia group. There were positive relationships between serum levels of PRL and serum levels of IL-1beta, IL-6 and TNF-alpha within the schizophrenia group. Within the schizophrenia group, TNF-alpha was the strongest predictor among the three cytokines for serum levels of prolactin after controlling for gender, age, education, smoking status and disease duration.</p> <p>Conclusions. Patients with normal weight, drug-naive, first-episode schizophrenia present elevated serum levels of PRL, which might be related to the up-regulated inflammatory status in this patient population.</p>
dc.identifier.submissionpathpsych_pp/662
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages546-52


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