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    The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the acute and continuation phases

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    Authors
    Keller, Martin B.
    Trivedi, Madhukar H.
    Thase, Michael E.
    Shelton, Richard C.
    Kornstein, Susan G.
    Nemeroff, Charles B.
    Friedman, Edward S.
    Gelenberg, Alan J.
    Kocsis, James H.
    Dunner, David L.
    Dunlop, Boadie W.
    Hirschfeld, Robert M.
    Rothschild, Anthony J.
    Ferguson, James M.
    Schatzberg, Alan F.
    Zajecka, John M.
    Pedersen, Ronald D.
    Yan, Bing
    Ahmed, Saeeduddin
    Schmidt, Michael
    Ninan, Philip T.
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    UMass Chan Affiliations
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    2007-09-11
    Keywords
    Adolescent
    Adult
    Analysis of Variance
    Antidepressive Agents, Second-Generation
    Cyclohexanols
    Depression
    Double-Blind Method
    Drug Administration Schedule
    Drug Evaluation
    Female
    Fluoxetine
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Recurrence
    Retrospective Studies
    Severity of Illness Index
    *Treatment Outcome
    Psychiatry
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    Link to Full Text
    http://dx.doi.org/10.1016/j.biopsych.2007.04.040
    Abstract
    BACKGROUND: We evaluated the comparative efficacy and safety of venlafaxine extended release (ER) and fluoxetine in the acute and continuation phases of treatment. METHODS: In this multicenter, double-blind study, outpatients with recurrent unipolar major depression were randomly assigned to receive venlafaxine ER (75-300 mg/day; n = 821) or fluoxetine (20-60 mg/day; n = 275). After a 10-week acute treatment phase, responders entered a 6-month continuation phase of ongoing therapy with double-blind venlafaxine ER (n = 530) or fluoxetine (n = 185). In the acute phase, the primary outcome was response, defined as a 17-item Hamilton Depression Rating Scale (HDRS) score < or =12 or > or =50% decrease from baseline; the secondary outcome was remission, defined as a HDRS score < or =7. In the continuation phase, the primary outcome was the proportion of patients who sustained response or remission. Secondary measures included time to onset of sustained response or remission (i.e., meeting criteria at two or more consecutive visits), relapse rates, and quality-of-life measures. RESULTS: At the acute treatment phase end point, response rates were 79% for both venlafaxine ER and fluoxetine; remission rates were 49% and 50% for venlafaxine ER and fluoxetine, respectively. In the continuation phase, response rates were 90% and 92%, and remission rates were 72% and 69% for venlafaxine ER and fluoxetine, respectively. Rates of sustained remission at the end of the continuation phase were 52% and 58% for venlafaxine ER and fluoxetine, respectively. CONCLUSION: Venlafaxine ER and fluoxetine were comparably effective during both acute and continuation phase therapy.
    Source
    Biol Psychiatry. 2007 Dec 15;62(12):1371-9. Epub 2007 Sep 7. Link to article on publisher's site
    DOI
    10.1016/j.biopsych.2007.04.040
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46143
    PubMed ID
    17825800
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.biopsych.2007.04.040
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