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    Enhancement in cognitive function recovery by granulocyte-colony stimulating factor in a rodent model of traumatic brain injury

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    Authors
    Sikoglu, Elif M.
    Heffernan, Meghan E.
    Tam, Kelly
    Sicard, Kenneth M.
    Bratane, Bernt T.
    Quan, Meina
    Fisher, Marc
    King, Jean A.
    UMass Chan Affiliations
    Department of Neurology
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    2014-02-01
    Keywords
    Animals
    Area Under Curve
    Brain Injuries
    Cognition Disorders
    Disease Models, Animal
    Granulocyte Colony-Stimulating Factor
    Male
    Neuropsychological Tests
    Rats
    Rats, Wistar
    Recovery of Function
    Time Factors
    Behavioral Neurobiology
    Mental and Social Health
    Nervous System Diseases
    Neurology
    Psychiatry
    Psychiatry and Psychology
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    Link to Full Text
    http://dx.doi.org/10.1016/j.bbr.2013.11.008
    Abstract
    Traumatic brain injury (TBI) is characterized by neuronal damage and commonly, secondary cell death, leading to functional and neurological dysfunction. Despite the recent focus of TBI research on developing therapies, affective therapeutic strategies targeting neuronal death associated with TBI remain underexplored. This study explored the efficacy of granulocyte-colony stimulating factor (G-CSF) as an intervention for improving cognitive deficits commonly associated with TBI. Although G-CSF has been studied with histological techniques, to date, its effects on functional outcome remain unknown. To this end, we used a closed head injury (CHI) model in Wistar rats that were randomly assigned to one of four groups (untreated TBI, G-CSF treated TBI, G-CSF treated Control, Control). The treatment groups were administered subcutaneous injections of G-CSF 30 min (120 mug/kg) and 12 h (60 mug/kg) post-trauma. The Morris Water Maze test was used to measure any treatment-associated changes in cognitive deficits observed in TBI animals at days 2-6 post-injury. Our findings demonstrate a significant improvement in cognitive performance in the G-CSF treated TBI animals within a week of injury, compared to untreated TBI, indicative of immediate and beneficial effect of G-CSF on cognitive performance post CHI. Our model suggests that early G-CSF exposure may be a promising therapeutic approach in recovery of cognitive deficits due to TBI.
    Source
    Behav Brain Res. 2014 Feb 1;259:354-6. doi: 10.1016/j.bbr.2013.11.008. Link to article on publisher's site
    DOI
    10.1016/j.bbr.2013.11.008
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46157
    PubMed ID
    24239694
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bbr.2013.11.008
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