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dc.contributor.authorCope, Lora M.
dc.contributor.authorVincent, Gina M.
dc.contributor.authorJobelius, Justin L.
dc.contributor.authorNyalakanti, Prashanth K.
dc.contributor.authorCalhoun, Vince D.
dc.contributor.authorKiehl, Kent A.
dc.date2022-08-11T08:10:29.000
dc.date.accessioned2022-08-23T17:10:56Z
dc.date.available2022-08-23T17:10:56Z
dc.date.issued2014-02-24
dc.date.submitted2014-09-16
dc.identifier.citationFront Hum Neurosci. 2014 Feb 24;8:87. doi: 10.3389/fnhum.2014.00087. <a href="http://dx.doi.org/10.3389/fnhum.2014.00087">Link to article on publisher's site</a>
dc.identifier.issn1662-5161 (Linking)
dc.identifier.doi10.3389/fnhum.2014.00087
dc.identifier.pmid24605095
dc.identifier.urihttp://hdl.handle.net/20.500.14038/46161
dc.description.abstractRecent neuroscientific evidence indicates that psychopathy is associated with abnormal function and structure in limbic and paralimbic areas. Psychopathy and substance use disorders are highly comorbid, but clinical experience suggests that psychopaths abuse drugs for different reasons than non-psychopaths, and that psychopaths do not typically experience withdrawal and craving upon becoming incarcerated. These neurobiological abnormalities may be related to psychopaths' different motivations for-and symptoms of-drug use. This study examined the modulatory effect of psychopathic traits on the neurobiological craving response to pictorial drug stimuli. Drug-related pictures and neutral pictures were presented and rated by participants while hemodynamic activity was monitored using functional magnetic resonance imaging. These data were collected at two correctional facilities in New Mexico using the Mind Research Network mobile magnetic resonance imaging system. The sample comprised 137 incarcerated adult males and females (93 females) with histories of substance dependence. The outcome of interest was the relation between psychopathy scores (using the Hare Psychopathy Checklist-Revised) and hemodynamic activity associated with viewing drug-related pictures vs. neutral pictures. There was a negative association between psychopathy scores and hemodynamic activity for viewing drug-related cues in the anterior cingulate, posterior cingulate, hippocampus, amygdala, caudate, globus pallidus, and parts of the prefrontal cortex. Psychopathic traits modulate the neurobiological craving response and suggest that individual differences are important for understanding and treating substance abuse.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24605095&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00087/full
dc.rights<p>Copyright 2014 Cope, Vincent, Jobelius, Nyalakanti, Calhoun and Kiehl. This is an open-access article distributed under the terms of the <a href="http://creativecommons.org/licenses/by/3.0/" target="_blank">Creative Commons Attribution License (CC BY)</a>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
dc.subjectdrug craving
dc.subjectfMRI
dc.subjectincarcerated offenders
dc.subjectparalimbic system
dc.subjectpsychopathic traits
dc.subjectsubstance dependence
dc.subjectBehavioral Neurobiology
dc.subjectMental and Social Health
dc.subjectNeuroscience and Neurobiology
dc.subjectPsychiatry
dc.subjectPsychiatry and Psychology
dc.subjectPsychology
dc.subjectSubstance Abuse and Addiction
dc.titlePsychopathic traits modulate brain responses to drug cues in incarcerated offenders
dc.typeJournal Article
dc.source.journaltitleFrontiers in human neuroscience
dc.source.volume8
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1696&amp;context=psych_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/696
dc.identifier.contextkey6123911
refterms.dateFOA2022-08-23T17:10:57Z
html.description.abstract<p>Recent neuroscientific evidence indicates that psychopathy is associated with abnormal function and structure in limbic and paralimbic areas. Psychopathy and substance use disorders are highly comorbid, but clinical experience suggests that psychopaths abuse drugs for different reasons than non-psychopaths, and that psychopaths do not typically experience withdrawal and craving upon becoming incarcerated. These neurobiological abnormalities may be related to psychopaths' different motivations for-and symptoms of-drug use. This study examined the modulatory effect of psychopathic traits on the neurobiological craving response to pictorial drug stimuli. Drug-related pictures and neutral pictures were presented and rated by participants while hemodynamic activity was monitored using functional magnetic resonance imaging. These data were collected at two correctional facilities in New Mexico using the Mind Research Network mobile magnetic resonance imaging system. The sample comprised 137 incarcerated adult males and females (93 females) with histories of substance dependence. The outcome of interest was the relation between psychopathy scores (using the Hare Psychopathy Checklist-Revised) and hemodynamic activity associated with viewing drug-related pictures vs. neutral pictures. There was a negative association between psychopathy scores and hemodynamic activity for viewing drug-related cues in the anterior cingulate, posterior cingulate, hippocampus, amygdala, caudate, globus pallidus, and parts of the prefrontal cortex. Psychopathic traits modulate the neurobiological craving response and suggest that individual differences are important for understanding and treating substance abuse.</p>
dc.identifier.submissionpathpsych_pp/696
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages87


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