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    Anomalous gray matter structural networks in recent onset post-traumatic stress disorder

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    Authors
    Qi, Shun
    Mu, Yun-Feng
    Cui, Long-Biao
    Zhang, Jian
    Guo, Fan
    Tan, Qing-Rong
    Shi, Mei
    Liu, Kang
    Xi, Yi-Bin
    Zhang, Nan-Yin
    Zhang, Xiao-Liang
    He, Yong
    Yang, Jian
    Yin, Hong
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    UMass Chan Affiliations
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    2017-03-14
    Keywords
    Cortex thickness
    Gray matter
    Post-traumatic stress disorder
    Small world networks
    Structural networks
    Mental and Social Health
    Neuroscience and Neurobiology
    Psychiatric and Mental Health
    Psychiatry
    Psychiatry and Psychology
    
    Metadata
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    Link to Full Text
    https://doi.org/10.1007/s11682-017-9693-z
    Abstract
    Alterations of the topological organization of abnormal regions or network-level structural aberrations are still poorly understood for post-traumatic stress disorder (PTSD). Herein, we investigated brain structural networks in recent-onset PTSD patients, all affected by the coalmine-flood disaster. Cortical networks were studied in recent onset PTSD patients (n = 15) and matched healthy controls (n = 25). Cortical networks were constructed by thresholding correlation matrices of 150 regions and quantified using graph theoretical approaches. Contributions of high-degree nodes, and regional and global network measures, including degree and betweenness, were studied. Compared with healthy controls, PTSD patients showed altered quantitative values in global network properties, characterized by shorter path length and higher clustering. Moreover, PTSD patients exhibited decreased connectivity in the right lingual gyrus, parahippocampal gyrus, left supramarginal gyrus, parahippocampal gyrus, bilateral superior and inferior frontal gyrus, superior frontal gyrus, and posterior cingulate gyrus. Nodal centrality decreased predominantly in the occipital regions (lingual gyrus) and default-mode regions, while increased correlations and centralities were observed in the medial temporal lobe and posterior cingulate cortex. PTSD-related networks exhibited a less efficient organization and regional connectivity. According to these findings, we conclude that regional connections involving fear-processing and re-experiential-processing cortex may play a role in maintaining or adapting to PTSD pathology.
    Source
    Brain Imaging Behav. 2017 Mar 14. doi: 10.1007/s11682-017-9693-z. Link to article on publisher's site
    DOI
    10.1007/s11682-017-9693-z
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46208
    PubMed ID
    28293804
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11682-017-9693-z
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