Anomalous gray matter structural networks in recent onset post-traumatic stress disorder
Authors
Qi, ShunMu, Yun-Feng
Cui, Long-Biao
Zhang, Jian
Guo, Fan
Tan, Qing-Rong
Shi, Mei
Liu, Kang
Xi, Yi-Bin
Zhang, Nan-Yin
Zhang, Xiao-Liang
He, Yong
Yang, Jian
Yin, Hong
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2017-03-14Keywords
Cortex thicknessGray matter
Post-traumatic stress disorder
Small world networks
Structural networks
Mental and Social Health
Neuroscience and Neurobiology
Psychiatric and Mental Health
Psychiatry
Psychiatry and Psychology
Metadata
Show full item recordAbstract
Alterations of the topological organization of abnormal regions or network-level structural aberrations are still poorly understood for post-traumatic stress disorder (PTSD). Herein, we investigated brain structural networks in recent-onset PTSD patients, all affected by the coalmine-flood disaster. Cortical networks were studied in recent onset PTSD patients (n = 15) and matched healthy controls (n = 25). Cortical networks were constructed by thresholding correlation matrices of 150 regions and quantified using graph theoretical approaches. Contributions of high-degree nodes, and regional and global network measures, including degree and betweenness, were studied. Compared with healthy controls, PTSD patients showed altered quantitative values in global network properties, characterized by shorter path length and higher clustering. Moreover, PTSD patients exhibited decreased connectivity in the right lingual gyrus, parahippocampal gyrus, left supramarginal gyrus, parahippocampal gyrus, bilateral superior and inferior frontal gyrus, superior frontal gyrus, and posterior cingulate gyrus. Nodal centrality decreased predominantly in the occipital regions (lingual gyrus) and default-mode regions, while increased correlations and centralities were observed in the medial temporal lobe and posterior cingulate cortex. PTSD-related networks exhibited a less efficient organization and regional connectivity. According to these findings, we conclude that regional connections involving fear-processing and re-experiential-processing cortex may play a role in maintaining or adapting to PTSD pathology.Source
Brain Imaging Behav. 2017 Mar 14. doi: 10.1007/s11682-017-9693-z. Link to article on publisher's siteDOI
10.1007/s11682-017-9693-zPermanent Link to this Item
http://hdl.handle.net/20.500.14038/46208PubMed ID
28293804Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/s11682-017-9693-z