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    Quantitative EEG during normal aging: association with the Alzheimer's disease genetic risk variant in PICALM gene

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    Authors
    Ponomareva, Natalya V.
    Andreeva, Tatiana V.
    Protasova, Maria S.
    Shagam, Lef I.
    Malina, Daria D.
    Goltsov, Andrey Yu.
    Fokin, Vitaly F.
    Illarioshkin, Sergey N.
    Rogaev, Evgeny I.
    UMass Chan Affiliations
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute
    Document Type
    Journal Article
    Publication Date
    2017-03-01
    Keywords
    Aging
    Alzheimer's disease (AD)
    Electroencephalography (EEG)
    PICALM
    Nervous System Diseases
    Neuroscience and Neurobiology
    Psychiatry
    Psychiatry and Psychology
    
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    Link to Full Text
    https://doi.org/10.1016/j.neurobiolaging.2016.12.010
    Abstract
    Genome-wide association studies have identified novel risk variants for Alzheimer's disease (AD). Among these, a gene carrying one of the highest risks for AD is PICALM. The PICALM rs3851179 A allele is thought to have a protective effect, whereas the G allele appears to confer risk for AD. The influence of the PICALM genotype on brain function in nondemented subjects remains largely unknown. We examined the possible effect of the PICALM rs3851179 genotype on quantitative electroencephalography recording at rest in 137 nondemented volunteers (age range: 20-79 years) subdivided into cohorts of those younger than and those older than 50 years of age. The homozygous presence of the AD risk variant PICALM GG was associated with an increase in beta relative power, with the effect being more pronounced in the older cohort. Beta power elevation in resting-state electroencephalography has previously been linked to cortical disinhibition and hyperexcitability. The increase in beta relative power in the carriers of the AD risk PICALM GG genotype suggests changes in the cortical excitatory-inhibitory balance, which are heightened during normal aging.
    Source
    Neurobiol Aging. 2017 Mar;51:177.e1-177.e8. doi: 10.1016/j.neurobiolaging.2016.12.010. Epub 2016 Dec 20. Link to article on publisher's site
    DOI
    10.1016/j.neurobiolaging.2016.12.010
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46214
    PubMed ID
    28073596
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neurobiolaging.2016.12.010
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