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    Altered neural connectivity in adult female rats exposed to early life social stress

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    Authors
    Nephew, Benjamin C.
    Huang, Wei
    Poirier, Guillaume L.
    Payne, Laurellee
    King, Jean A.
    UMass Chan Affiliations
    Center for Comparative NeuroImaging, Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    2017-01-01
    Keywords
    Hippocampus
    Nucleus accumbens
    Prefrontal cortex
    Resting state functional connectivity
    Social stress
    fMRI
    Mental and Social Health
    Neuroscience and Neurobiology
    Psychiatry
    Psychiatry and Psychology
    
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    https://doi.org/10.1016/j.bbr.2016.08.051
    Abstract
    The use of a variety of neuroanatomical techniques has led to a greater understanding of the adverse effects of stress on psychiatric health. One recent advance that has been particularly valuable is the development of resting state functional connectivity (RSFC) in clinical studies. The current study investigates changes in RSFC in F1 adult female rats exposed to the early life chronic social stress (ECSS) of the daily introduction of a novel male intruder to the cage of their F0 mothers while the F1 pups are in the cage. This ECSS for the F1 animals consists of depressed maternal care from their F0 mothers and exposure to conflict between their F0 mothers and intruder males. Analyses of the functional connectivity data in ECSS exposed adult females versus control females reveal broad changes in the limbic and reward systems, the salience and introspective socioaffective networks, and several additional stress and social behavior associated nuclei. Substantial changes in connectivity were found in the prefrontal cortex, nucleus accumbens, hippocampus, and somatosensory cortex. The current rodent RSFC data support the hypothesis that the exposure to early life social stress has long term effects on neural connectivity in numerous social behavior, stress, and depression relevant brain nuclei. Future conscious rodent RSFC studies can build on the wealth of data generated from previous neuroanatomical studies of early life stress and enhance translational connectivity between animal and human fMRI studies in the development of novel preventative measures and treatments.
    Source
    Behav Brain Res. 2017 Jan 1;316:225-233 Link to article on publisher's site
    DOI
    10.1016/j.bbr.2016.08.051
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46231
    PubMed ID
    27594665
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bbr.2016.08.051
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