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dc.contributor.authorNephew, Benjamin C.
dc.contributor.authorHuang, Wei
dc.contributor.authorPoirier, Guillaume L.
dc.contributor.authorPayne, Laurellee
dc.contributor.authorKing, Jean A.
dc.date2022-08-11T08:10:30.000
dc.date.accessioned2022-08-23T17:11:14Z
dc.date.available2022-08-23T17:11:14Z
dc.date.issued2017-01-01
dc.date.submitted2017-04-05
dc.identifier.citationBehav Brain Res. 2017 Jan 1;316:225-233 <a href="https://doi.org/10.1016/j.bbr.2016.08.051">Link to article on publisher's site</a>
dc.identifier.issn0166-4328 (Linking)
dc.identifier.doi10.1016/j.bbr.2016.08.051
dc.identifier.pmid27594665
dc.identifier.urihttp://hdl.handle.net/20.500.14038/46231
dc.description.abstractThe use of a variety of neuroanatomical techniques has led to a greater understanding of the adverse effects of stress on psychiatric health. One recent advance that has been particularly valuable is the development of resting state functional connectivity (RSFC) in clinical studies. The current study investigates changes in RSFC in F1 adult female rats exposed to the early life chronic social stress (ECSS) of the daily introduction of a novel male intruder to the cage of their F0 mothers while the F1 pups are in the cage. This ECSS for the F1 animals consists of depressed maternal care from their F0 mothers and exposure to conflict between their F0 mothers and intruder males. Analyses of the functional connectivity data in ECSS exposed adult females versus control females reveal broad changes in the limbic and reward systems, the salience and introspective socioaffective networks, and several additional stress and social behavior associated nuclei. Substantial changes in connectivity were found in the prefrontal cortex, nucleus accumbens, hippocampus, and somatosensory cortex. The current rodent RSFC data support the hypothesis that the exposure to early life social stress has long term effects on neural connectivity in numerous social behavior, stress, and depression relevant brain nuclei. Future conscious rodent RSFC studies can build on the wealth of data generated from previous neuroanatomical studies of early life stress and enhance translational connectivity between animal and human fMRI studies in the development of novel preventative measures and treatments.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27594665&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://doi.org/10.1016/j.bbr.2016.08.051
dc.subjectHippocampus
dc.subjectNucleus accumbens
dc.subjectPrefrontal cortex
dc.subjectResting state functional connectivity
dc.subjectSocial stress
dc.subjectfMRI
dc.subjectMental and Social Health
dc.subjectNeuroscience and Neurobiology
dc.subjectPsychiatry
dc.subjectPsychiatry and Psychology
dc.titleAltered neural connectivity in adult female rats exposed to early life social stress
dc.typeJournal Article
dc.source.journaltitleBehavioural brain research
dc.source.volume316
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/767
dc.identifier.contextkey9981509
html.description.abstract<p>The use of a variety of neuroanatomical techniques has led to a greater understanding of the adverse effects of stress on psychiatric health. One recent advance that has been particularly valuable is the development of resting state functional connectivity (RSFC) in clinical studies. The current study investigates changes in RSFC in F1 adult female rats exposed to the early life chronic social stress (ECSS) of the daily introduction of a novel male intruder to the cage of their F0 mothers while the F1 pups are in the cage. This ECSS for the F1 animals consists of depressed maternal care from their F0 mothers and exposure to conflict between their F0 mothers and intruder males. Analyses of the functional connectivity data in ECSS exposed adult females versus control females reveal broad changes in the limbic and reward systems, the salience and introspective socioaffective networks, and several additional stress and social behavior associated nuclei. Substantial changes in connectivity were found in the prefrontal cortex, nucleus accumbens, hippocampus, and somatosensory cortex. The current rodent RSFC data support the hypothesis that the exposure to early life social stress has long term effects on neural connectivity in numerous social behavior, stress, and depression relevant brain nuclei. Future conscious rodent RSFC studies can build on the wealth of data generated from previous neuroanatomical studies of early life stress and enhance translational connectivity between animal and human fMRI studies in the development of novel preventative measures and treatments.</p>
dc.identifier.submissionpathpsych_pp/767
dc.contributor.departmentCenter for Comparative NeuroImaging, Department of Psychiatry
dc.source.pages225-233


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