The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis
AuthorsJun-O'Connell, Adalia H.
Butala, Ankur A.
Morales, Idanis Berrios
Deligiannidis, Kristina M.
UMass Chan AffiliationsGraduate School of Biomedical Sciences, Millennium PhD Program
Systems and Psychosocial Advances Research Center
Department of Psychiatry, Center for Psychopharmacologic Research and Treatment
Department of Neurology
Document TypeJournal Article
KeywordsMental and Social Health
Nervous System Diseases
Neuroscience and Neurobiology
Psychiatry and Psychology
MetadataShow full item record
AbstractClinical observations of mood instability in multiple sclerosis (MS) have led to the hypothesis that bipolar disorder (BD) may be more prevalent in persons with MS than in the general population. This cross-sectional study assesses the prevalence of BD among patients with MS using standardized psychiatric diagnostic interviews and evaluates quality of life. This study demonstrates a higher prevalence of BD in patients with MS compared with the general population. It also reveals the negative impact of BD on quality of life, raises the concern that BD can occur before the onset of neurological symptoms in MS, and suggests that, in some cases, BD may delay diagnosis of MS.
SourceJ Neuropsychiatry Clin Neurosci. 2017 Winter;29(1):45-51. doi: 10.1176/appi.neuropsych.15120403. Epub 2016 Aug 19. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/46232
Co-author Nils Henninger is a doctoral student in the Millennium PhD Program (MPP) in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.
Related ResourcesLink to Article in PubMed