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    Awake whole-brain functional connectivity alterations in the adolescent spontaneously hypertensive rat feature visual streams and striatal networks

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    Authors
    Poirier, Guillaume L.
    Huang, Wei
    Tam, K.
    DiFranza, Joseph R.
    King, Jean A.
    UMass Chan Affiliations
    Department of Family Medicine and Community Health
    Department of Psychiatry, Center for Comparative NeuroImaging
    Document Type
    Journal Article
    Publication Date
    2016-09-30
    Keywords
    Attention deficit/hyperactivity disorder
    Basal ganglia
    Caudate
    Magnetic resonance imaging
    Neural network
    Neuroimaging
    Putamen
    Resting-state functional connectivity
    Spontaneously hypertensive rat
    Visual stream
    Mental Disorders
    Neuroscience and Neurobiology
    Psychiatry
    Psychiatry and Psychology
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    Link to Full Text
    https://doi.org/10.1007/s00429-016-1301-2
    Abstract
    Brain mechanisms underpinning attention deficit/hyperactivity disorder (ADHD) are incompletely understood. The adolescent spontaneously hypertensive rat (SHR) is a widely studied preclinical model that expresses several of the key behavioral features associated with ADHD. Yet, little is known about large-scale functional connectivity patterns in the SHR, and their potential similarity to those of humans with ADHD. Using an approach comparable to human studies, magnetic resonance imaging in the awake animal was performed to identify whole-brain intrinsic neural connectivity patterns. An independent components analysis of resting-state functional connectivity demonstrated many common components between the SHR and both Wistar Kyoto and Sprague-Dawley control strains, but there was a divergence in other networks. In the SHR, three functional networks involving the striatum had only weak correlations with networks in the two control strains. Conversely, networks involving the visual cortex that was present in both control strains had only weak correlations with networks in the SHR. The implication is that the patterns of brain activity differ between the SHR and the other strains, suggesting that brain connectivity patterns in this animal model of ADHD may provide insights into the neural basis of ADHD. Brain connectivity patterns might also serve to identify brain circuits that could be targeted for the manipulation and evaluation of potential therapeutic options.
    Source
    Brain Struct Funct. 2016 Sep 28. [Epub ahead of print] Link to article on publisher's site
    DOI
    10.1007/s00429-016-1301-2
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46250
    PubMed ID
    27680743
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00429-016-1301-2
    Scopus Count
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    UMass Chan Faculty and Researcher Publications

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