Awake whole-brain functional connectivity alterations in the adolescent spontaneously hypertensive rat feature visual streams and striatal networks
UMass Chan Affiliations
Department of Family Medicine and Community HealthDepartment of Psychiatry, Center for Comparative NeuroImaging
Document Type
Journal ArticlePublication Date
2016-09-30Keywords
Attention deficit/hyperactivity disorderBasal ganglia
Caudate
Magnetic resonance imaging
Neural network
Neuroimaging
Putamen
Resting-state functional connectivity
Spontaneously hypertensive rat
Visual stream
Mental Disorders
Neuroscience and Neurobiology
Psychiatry
Psychiatry and Psychology
Metadata
Show full item recordAbstract
Brain mechanisms underpinning attention deficit/hyperactivity disorder (ADHD) are incompletely understood. The adolescent spontaneously hypertensive rat (SHR) is a widely studied preclinical model that expresses several of the key behavioral features associated with ADHD. Yet, little is known about large-scale functional connectivity patterns in the SHR, and their potential similarity to those of humans with ADHD. Using an approach comparable to human studies, magnetic resonance imaging in the awake animal was performed to identify whole-brain intrinsic neural connectivity patterns. An independent components analysis of resting-state functional connectivity demonstrated many common components between the SHR and both Wistar Kyoto and Sprague-Dawley control strains, but there was a divergence in other networks. In the SHR, three functional networks involving the striatum had only weak correlations with networks in the two control strains. Conversely, networks involving the visual cortex that was present in both control strains had only weak correlations with networks in the SHR. The implication is that the patterns of brain activity differ between the SHR and the other strains, suggesting that brain connectivity patterns in this animal model of ADHD may provide insights into the neural basis of ADHD. Brain connectivity patterns might also serve to identify brain circuits that could be targeted for the manipulation and evaluation of potential therapeutic options.Source
Brain Struct Funct. 2016 Sep 28. [Epub ahead of print] Link to article on publisher's siteDOI
10.1007/s00429-016-1301-2Permanent Link to this Item
http://hdl.handle.net/20.500.14038/46250PubMed ID
27680743Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/s00429-016-1301-2