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    Increased Depression and Anxiety Symptoms are Associated with More Breakdowns in Cognitive Control to Cocaine Cues in Veterans with Cocaine Use Disorder

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    Authors
    DiGirolamo, Gregory J.
    Gonzalez, Gerardo
    Smelson, David A.
    Guevremont, Nathan
    Andre, Michael I.
    Patnaik, Pooja O.
    Zaniewski, Zachary R.
    UMass Chan Affiliations
    Implementation Science and Practice Advances Research Center
    Department of Psychiatry
    Department of Radiology
    Document Type
    Journal Article
    Publication Date
    2017-11-09
    Keywords
    Cocaine
    addiction
    antisaccades
    cognitive control
    mood disorders
    veterans
    Mental Disorders
    Military and Veterans Studies
    Psychiatry
    Psychiatry and Psychology
    Substance Abuse and Addiction
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090533/
    Abstract
    OBJECTIVE: Cue-elicited craving is a clinically important aspect of cocaine addiction directly linked to cognitive control breakdowns and relapse to cocaine-taking behavior. However, whether craving drives breakdowns in cognitive control toward cocaine cues in veterans, who experience significantly more co-occurring mood disorders, is unknown. The present study tests whether veterans have breakdowns in cognitive control because of cue-elicited craving or current anxiety or depression symptoms. METHODS: Twenty-four veterans with cocaine use disorder were cue-exposed, then tested on an antisaccade task in which participants were asked to control their eye movements toward cocaine or neutral cues by looking away from the cue. The relationship among cognitive control breakdowns (as measured by eye errors), cue-induced craving (changes in self-reported craving following cocaine cue exposure), and mood measures (depression and anxiety) was investigated. RESULTS: Veterans made significantly more errors toward cocaine cues than neutral cues. Depression and anxiety scores, but not cue-elicited craving, were significantly associated with increased subsequent errors toward cocaine cues for veterans. CONCLUSIONS: Increased depression and anxiety are specifically related to more cognitive control breakdowns toward cocaine cues in veterans. Depression and anxiety must be considered further in the etiology and treatment of cocaine use disorder in veterans. Furthermore, treating depression and anxiety as well, rather than solely alleviating craving levels, may prove a more effective combined treatment option in veterans with cocaine use disorder.
    Source

    J Dual Diagn. 2017 Oct-Dec;13(4):298-304. doi: 10.1080/15504263.2017.1360535. Epub 2017 Nov 9. Link to article on publisher's site

    DOI
    10.1080/15504263.2017.1360535
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46299
    PubMed ID
    29120266
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1080/15504263.2017.1360535
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