• Login
    View Item 
    •   Home
    • UMass Chan Faculty and Staff Research and Publications
    • UMass Chan Faculty and Researcher Publications
    • View Item
    •   Home
    • UMass Chan Faculty and Staff Research and Publications
    • UMass Chan Faculty and Researcher Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywords

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    The Possible Role of the Angiotensin System in the Pathophysiology of Schizophrenia: Implications for Pharmacotherapy

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Oh, SeungJu Jackie
    Fan, Xiaoduo
    UMass Chan Affiliations
    School of Medicine
    Psychotic Disorders Program, UMass Memorial Medical Center
    Implementation Science and Practice Advances Research Center
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    2019-06-01
    Keywords
    Amino Acids, Peptides, and Proteins
    Biochemical Phenomena, Metabolism, and Nutrition
    Cellular and Molecular Physiology
    Mental and Social Health
    Mental Disorders
    Nervous System
    Neuroscience and Neurobiology
    Pharmacology, Toxicology and Environmental Health
    Psychiatry
    Psychiatry and Psychology
    Therapeutics
    Show allShow less
    
    Metadata
    Show full item record
    Link to Full Text
    https://doi.org/10.1007/s40263-019-00632-4
    Abstract
    A growing body of literature has elucidated the involvement of the central renin-angiotensin system (RAS) in various neuropsychiatric diseases. While consensus on the exact mechanism of the central RAS in schizophrenia pathophysiology does not currently exist, increasing evidence reveals promise in harnessing the therapeutic potential of RAS modulation in the treatment of schizophrenia. In this review, we examine how the central RAS affects inflammation, glutamate, dopamine, gamma-aminobutyric acid (GABA), and peroxisome proliferator-activated receptor (PPAR)-gamma, all of which are associated with schizophrenia etiology. In addition, a recent study has demonstrated the therapeutic potential of RAS modulators, especially angiotensin II type 1 receptor blockers (ARBs), as adjunctive therapy to the currently available antipsychotic medications for schizophrenia treatment. With a greater understanding of how RAS inhibition directly modulates neurotransmitter balance in the brain, it is possible that compounds with RAS-inhibiting properties could be used to optimize physiological levels of glutamate, dopamine, and GABA, and the balance among the three neurotransmitters, analogously to how antipsychotic medications mediate the dopaminergic pathways. It can be hoped that a novel approach based on this concept, such as adjunctive telmisartan therapy, may offer practical interventional strategies to address currently unmet therapeutic needs in patients with schizophrenia, especially those with treatment-resistant schizophrenia.
    Source

    CNS Drugs. 2019 Jun;33(6):539-547. doi: 10.1007/s40263-019-00632-4. Link to article on publisher's site

    DOI
    10.1007/s40263-019-00632-4
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46305
    PubMed ID
    30993607
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1007/s40263-019-00632-4
    Scopus Count
    Collections
    T.H. Chan School of Medicine Student Publications
    UMass Chan Faculty and Researcher Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.