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dc.contributor.authorWharam, Moody D.
dc.contributor.authorMeza, Jane
dc.contributor.authorAnderson, James
dc.contributor.authorBreneman, John C.
dc.contributor.authorDonaldson, Sarah S.
dc.contributor.authorFitzGerald, Thomas J.
dc.contributor.authorMichalski, Jeff
dc.contributor.authorTeot, Lisa A.
dc.contributor.authorWiener, Eugene S.
dc.contributor.authorMeyer, William H.
dc.date2022-08-11T08:10:32.000
dc.date.accessioned2022-08-23T17:12:26Z
dc.date.available2022-08-23T17:12:26Z
dc.date.issued2004-05-01
dc.date.submitted2017-04-24
dc.identifier.citationJ Clin Oncol. 2004 May 15;22(10):1902-8. <a href="https://doi.org/10.1200/JCO.2004.08.124">Link to article on publisher's site</a>
dc.identifier.issn0732-183X (Linking)
dc.identifier.doi10.1200/JCO.2004.08.124
dc.identifier.pmid15143083
dc.identifier.urihttp://hdl.handle.net/20.500.14038/46503
dc.description.abstractPURPOSE: To analyze patterns of failure and factors predictive of local treatment failure in children enrolled on the third Intergroup Rhabdomyosarcoma Study who had either biopsy only or subtotal resection of their primary tumor, had no distant metastases, and received radiation therapy for local control. PATIENTS AND METHODS: Treatment failure was categorized as local, regional nodal, or distant metastatic. The 5-year cumulative risk of failure was estimated for each category and factors predictive of local failure risk were determined using the Cox model and binary recursive partitioning. RESULTS: The estimated 5-year cumulative incidence rates by failure category were: total local (with or without concurrent regional or distant failure), 19%; total regional nodal, 2%; total distant, 11%; and death from toxicity or unknown recurrence type, 4%. Lymph node involvement at diagnosis was the single factor most predictive of increased total local failure risk (5-year cumulative incidence 32%) compared with children with negative nodes or unknown node status (16%). No significant effect on local failure risk was observed by total radiotherapy dose over the prescribed range of 41.4 Gy to 50.4 Gy. For all patients (N = 405), the estimated 5-year failure-free survival and overall survival were, respectively, 70% and 78%. CONCLUSION: Local failure after radiotherapy for group III rhabdomyosarcoma patients is the predominant type of relapse. Involved lymph nodes at diagnosis predict a higher risk of local and distant treatment failure compared with patients whose lymph nodes are negative.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15143083&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://doi.org/10.1200/JCO.2004.08.124
dc.subjectHealth Services Administration
dc.subjectNeoplasms
dc.subjectOncology
dc.subjectRadiology
dc.titleFailure pattern and factors predictive of local failure in rhabdomyosarcoma: a report of group III patients on the third Intergroup Rhabdomyosarcoma Study
dc.typeJournal Article
dc.source.journaltitleJournal of clinical oncology : official journal of the American Society of Clinical Oncology
dc.source.volume22
dc.source.issue10
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qarc/53
dc.identifier.contextkey10067903
html.description.abstract<p>PURPOSE: To analyze patterns of failure and factors predictive of local treatment failure in children enrolled on the third Intergroup Rhabdomyosarcoma Study who had either biopsy only or subtotal resection of their primary tumor, had no distant metastases, and received radiation therapy for local control.</p> <p>PATIENTS AND METHODS: Treatment failure was categorized as local, regional nodal, or distant metastatic. The 5-year cumulative risk of failure was estimated for each category and factors predictive of local failure risk were determined using the Cox model and binary recursive partitioning.</p> <p>RESULTS: The estimated 5-year cumulative incidence rates by failure category were: total local (with or without concurrent regional or distant failure), 19%; total regional nodal, 2%; total distant, 11%; and death from toxicity or unknown recurrence type, 4%. Lymph node involvement at diagnosis was the single factor most predictive of increased total local failure risk (5-year cumulative incidence 32%) compared with children with negative nodes or unknown node status (16%). No significant effect on local failure risk was observed by total radiotherapy dose over the prescribed range of 41.4 Gy to 50.4 Gy. For all patients (N = 405), the estimated 5-year failure-free survival and overall survival were, respectively, 70% and 78%.</p> <p>CONCLUSION: Local failure after radiotherapy for group III rhabdomyosarcoma patients is the predominant type of relapse. Involved lymph nodes at diagnosis predict a higher risk of local and distant treatment failure compared with patients whose lymph nodes are negative.</p>
dc.identifier.submissionpathqarc/53
dc.contributor.departmentDepartment of Radiation Oncology
dc.contributor.departmentQuality Assurance Review Center
dc.source.pages1902-8


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