• Login
    View Item 
    •   Home
    • UMass Chan Departments, Programs and Centers
    • Radiation Oncology Publications
    • View Item
    •   Home
    • UMass Chan Departments, Programs and Centers
    • Radiation Oncology Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywords

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    A comparative study of the long term psychosocial functioning of childhood acute lymphoblastic leukemia survivors treated by intrathecal methotrexate with or without cranial radiation

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Hill, James M.
    Kornblith, Alice B.
    Jones, Dana
    Freeman, Arnold
    Holland, James F.
    Glicksman, Arvin S.
    Boyett, James M.
    Lenherr, Beat
    Brecher, Martin L.
    Dubowy, Ronald
    Kung, Faith
    Maurer, Harold
    Holland, Jimmie C.
    Show allShow less
    UMass Chan Affiliations
    Quality Assurance Review Center
    Document Type
    Journal Article
    Publication Date
    1998-01-01
    Keywords
    Health Services Administration
    Neoplasms
    Oncology
    Radiology
    
    Metadata
    Show full item record
    Link to Full Text
    http://dx.doi.org/10.1002/(SICI)1097-0142(19980101)82:1<208::AID-CNCR26>3.0.CO;2-5
    Abstract
    BACKGROUND: Although previous research has delineated medical, cognitive, and neuropsychologic late effects of central nervous system (CNS) prophylaxis for childhood acute lymphoblastic leukemia (ALL), it has been difficult to draw conclusions about the long term psychosocial sequelae of these treatments due to methodologic problems that led to inconclusive results in past studies. In the current study, the authors examined the long term psychosocial functioning of childhood ALL survivors who had been treated on a Phase III clinical protocol (Cancer and Leukemia Group B [CALGB] 7611) between 1976 and 1979, in which they were randomized to receive either 2400 centigray of cranial radiation (CRT) with intrathecal methotrexate (IT-MTX) or intermediate dose systemic methotrexate (IV-MTX) with IT-MTX. METHODS: One hundred ten survivors of childhood ALL (mean age, 20.8 years) treated on CALGB 7611 who were age 14 years or older and disease free for at least 1 year were studied a mean of 14.7 years after their entry on CALGB 7611. In a telephone interview, a psychosocial assessment battery was administered to the patients, consisting of measures that assessed psychologic, sexual, social, and vocational functioning as well as any delayed physical effects. RESULTS: Survivors who had received CRT + IT-MTX had significantly poorer academic achievement (P = 0.0001), poorer self-images with regard to their bodies (P = 0.001), and greater psychologic distress (P = 0.005). CONCLUSIONS: Cranial radiation used to treat children with ALL has significant long term sequelae in terms of poorer academic achievement and psychosocial functioning. These data add weight to the conclusion that CRT prophylaxis should only be used to treat children who are at high risk of CNS relapse.
    Source
    Cancer. 1998 Jan 1;82(1):208-18.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46518
    PubMed ID
    9428499
    Related Resources
    Link to Article in PubMed
    Collections
    Radiation Oncology Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.