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    Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin

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    J_biom_optics_chin_et_al_2012.pdf
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    Authors
    Chin, Michael S.
    Freniere, Brian B.
    Lo, Yuan-Chyuan
    Saleeby, Jonathan H.
    Baker, Stephen P.
    Strom, Heather M.
    Ignotz, Ronald A.
    Lalikos, Janice F.
    Fitzgerald, Thomas J.
    UMass Chan Affiliations
    Senior Scholars Program
    School of Medicine
    Department of Radiation Oncology
    Department of Surgery
    Center for Academic Achievement
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2012-03-05
    Keywords
    Animals
    Mice
    Mice, Nude
    Oximetry
    *Oxygen Consumption
    Perfusion Imaging
    Radiodermatitis
    Reproducibility of Results
    Sensitivity and Specificity
    Biomedical Engineering and Bioengineering
    Biostatistics
    Epidemiology
    Health Services Research
    Oncology
    Radiology
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    Link to Full Text
    http://dx.doi.org/10.1117/1.JBO.17.2.026010
    Abstract
    Studies examining acute oxygenation and perfusion changes in irradiated skin are limited. Hyperspectral imaging (HSI), a method of wide-field, diffuse reflectance spectroscopy, provides noninvasive, quantified measurements of cutaneous oxygenation and perfusion. This study examines whether HSI can assess acute changes in oxygenation and perfusion following irradiation. Skin on both flanks of nude mice (n=20) was exposed to 50 Gy of beta radiation from a strontium-90 source. Hyperspectral images were obtained before irradiation and on selected days for three weeks. Skin reaction assessment was performed concurrently with HSI. Desquamative injury formed in all irradiated areas. Skin reactions were first seen on day 7, with peak formation on day 14, and resolution beginning by day 21. HSI demonstrated increased tissue oxygenation on day 1 before cutaneous changes were observed (p
    Source
    Chin MS, Freniere BB, Lo Y, et al; Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin. J. Biomed. Opt. 0001;17(2):026010-1-026010-5. doi:10.1117/1.JBO.17.2.026010. Link to article on publisher's site
    DOI
    10.1117/1.JBO.17.2.026010
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46558
    PubMed ID
    22463042
    Notes

    Medical student Brian Freniere participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.

    Related Resources
    Link to Article in PubMed
    Rights
    Copyright 2009 Society of Photo-Optical Instrumentation Engineers. Publisher PDF posted as allowed by the publisher's author rights policy at http://spie.org/x85011.xml.
    ae974a485f413a2113503eed53cd6c53
    10.1117/1.JBO.17.2.026010
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