Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin

Chin, Michael S.; Freniere, Brian B.; Lo, Yuan-Chyuan; Saleeby, Jonathan H.; Baker, Stephen P.; Strom, Heather M.; Ignotz, Ronald A.; Lalikos, Janice F.; Fitzgerald, Thomas J.

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http://dx.doi.org/10.1117/1.JBO.17.2.026010

Abstract

Studies examining acute oxygenation and perfusion changes in irradiated skin are limited. Hyperspectral imaging (HSI), a method of wide-field, diffuse reflectance spectroscopy, provides noninvasive, quantified measurements of cutaneous oxygenation and perfusion. This study examines whether HSI can assess acute changes in oxygenation and perfusion following irradiation. Skin on both flanks of nude mice (n=20) was exposed to 50 Gy of beta radiation from a strontium-90 source. Hyperspectral images were obtained before irradiation and on selected days for three weeks. Skin reaction assessment was performed concurrently with HSI. Desquamative injury formed in all irradiated areas. Skin reactions were first seen on day 7, with peak formation on day 14, and resolution beginning by day 21. HSI demonstrated increased tissue oxygenation on day 1 before cutaneous changes were observed (p

Source

Chin MS, Freniere BB, Lo Y, et al; Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin. J. Biomed. Opt. 0001;17(2):026010-1-026010-5. doi:10.1117/1.JBO.17.2.026010. Link to article on publisher's site

DOI

10.1117/1.JBO.17.2.026010

Permanent Link to this Item

http://hdl.handle.net/20.500.14038/46558

PubMed ID

22463042

Notes

Medical student Brian Freniere participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.