Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin
AuthorsChin, Michael S.
Freniere, Brian B.
Saleeby, Jonathan H.
Baker, Stephen P.
Strom, Heather M.
Ignotz, Ronald A.
Lalikos, Janice F.
Fitzgerald, Thomas J.
UMass Chan AffiliationsSenior Scholars Program
School of Medicine
Department of Radiation Oncology
Department of Surgery
Center for Academic Achievement
Department of Quantitative Health Sciences
Reproducibility of Results
Sensitivity and Specificity
Biomedical Engineering and Bioengineering
Health Services Research
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AbstractStudies examining acute oxygenation and perfusion changes in irradiated skin are limited. Hyperspectral imaging (HSI), a method of wide-field, diffuse reflectance spectroscopy, provides noninvasive, quantified measurements of cutaneous oxygenation and perfusion. This study examines whether HSI can assess acute changes in oxygenation and perfusion following irradiation. Skin on both flanks of nude mice (n=20) was exposed to 50 Gy of beta radiation from a strontium-90 source. Hyperspectral images were obtained before irradiation and on selected days for three weeks. Skin reaction assessment was performed concurrently with HSI. Desquamative injury formed in all irradiated areas. Skin reactions were first seen on day 7, with peak formation on day 14, and resolution beginning by day 21. HSI demonstrated increased tissue oxygenation on day 1 before cutaneous changes were observed (p
SourceChin MS, Freniere BB, Lo Y, et al; Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin. J. Biomed. Opt. 0001;17(2):026010-1-026010-5. doi:10.1117/1.JBO.17.2.026010. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/46558
Medical student Brian Freniere participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.
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RightsCopyright 2009 Society of Photo-Optical Instrumentation Engineers. Publisher PDF posted as allowed by the publisher's author rights policy at http://spie.org/x85011.xml.