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dc.contributor.authorPiazza, Gregory
dc.contributor.authorGoldhaber, Samuel Z.
dc.contributor.authorKroll, Aimee
dc.contributor.authorGoldberg, Robert J.
dc.contributor.authorEmery, Catherine
dc.contributor.authorSpencer, Frederick A.
dc.date2022-08-11T08:10:33.000
dc.date.accessioned2022-08-23T17:12:42Z
dc.date.available2022-08-23T17:12:42Z
dc.date.issued2012-10-01
dc.date.submitted2012-10-23
dc.identifier.citationAm J Med. 2012 Oct;125(10):1010-8. doi: 10.1016/j.amjmed.2012.03.007. <a href="http://dx.doi.org/10.1016/j.amjmed.2012.03.007" target="_blank">Link to article on publisher's site</a>
dc.identifier.issn0002-9343 (Linking)
dc.identifier.doi10.1016/j.amjmed.2012.03.007
dc.identifier.pmid22884176
dc.identifier.urihttp://hdl.handle.net/20.500.14038/46560
dc.description.abstractOBJECTIVE: Our aim was to compare the clinical characteristics, prophylaxis, treatment, and outcomes of venous thromboembolism in patients with and without previously diagnosed chronic obstructive pulmonary disease. METHODS: We analyzed the population-based Worcester Venous Thromboembolism Study of 2488 consecutive patients with validated venous thromboembolism to compare clinical characteristics, prophylaxis, treatment, and outcomes in patients with and without chronic obstructive pulmonary disease. RESULTS: Of 2488 patients with venous thromboembolism, 484 (19.5%) had a history of clinical chronic obstructive pulmonary disease and 2004 (80.5%) did not. Patients with chronic obstructive pulmonary disease were older (mean age 68 vs 63 years) and had a higher frequency of heart failure (35.5% vs 12.9%) and immobility (53.5% vs 43.3%) than patients without chronic obstructive pulmonary disease (all P<.0001). Patients with chronic obstructive pulmonary disease were more likely to die in hospital (6.8% vs 4%, P=.01) and within 30 days of venous thromboembolism diagnosis (12.6% vs 6.5%, P<.0001). Patients with chronic obstructive pulmonary disease demonstrated increased mortality despite a higher frequency of venous thromboembolism prophylaxis. Immobility doubled the risk of in-hospital death (adjusted odds ratio, 2.21; 95% confidence interval, 1.35-3.62) and death within 30 days of venous thromboembolism diagnosis (adjusted odds ratio, 2.04; 95% confidence interval, 1.43-2.91). CONCLUSION: Patients with chronic obstructive pulmonary disease have an increased risk of dying during hospitalization and within 30 days of venous thromboembolism diagnosis. Immobility in patients with chronic obstructive pulmonary disease is an ominous risk factor for adverse outcomes.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=22884176&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.amjmed.2012.03.007
dc.subjectVenous Thrombosis
dc.subjectVenous Thromboembolism
dc.subjectLung Diseases
dc.subjectCardiovascular Diseases
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.subjectRespiratory Tract Diseases
dc.titleVenous thromboembolism in patients with chronic obstructive pulmonary disease
dc.typeJournal Article
dc.source.journaltitleThe American journal of medicine
dc.source.volume125
dc.source.issue10
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/1025
dc.identifier.contextkey3418820
html.description.abstract<p>OBJECTIVE: Our aim was to compare the clinical characteristics, prophylaxis, treatment, and outcomes of venous thromboembolism in patients with and without previously diagnosed chronic obstructive pulmonary disease.</p> <p>METHODS: We analyzed the population-based Worcester Venous Thromboembolism Study of 2488 consecutive patients with validated venous thromboembolism to compare clinical characteristics, prophylaxis, treatment, and outcomes in patients with and without chronic obstructive pulmonary disease.</p> <p>RESULTS: Of 2488 patients with venous thromboembolism, 484 (19.5%) had a history of clinical chronic obstructive pulmonary disease and 2004 (80.5%) did not. Patients with chronic obstructive pulmonary disease were older (mean age 68 vs 63 years) and had a higher frequency of heart failure (35.5% vs 12.9%) and immobility (53.5% vs 43.3%) than patients without chronic obstructive pulmonary disease (all P<.0001). Patients with chronic obstructive pulmonary disease were more likely to die in hospital (6.8% vs 4%, P=.01) and within 30 days of venous thromboembolism diagnosis (12.6% vs 6.5%, P<.0001). Patients with chronic obstructive pulmonary disease demonstrated increased mortality despite a higher frequency of venous thromboembolism prophylaxis. Immobility doubled the risk of in-hospital death (adjusted odds ratio, 2.21; 95% confidence interval, 1.35-3.62) and death within 30 days of venous thromboembolism diagnosis (adjusted odds ratio, 2.04; 95% confidence interval, 1.43-2.91).</p> <p>CONCLUSION: Patients with chronic obstructive pulmonary disease have an increased risk of dying during hospitalization and within 30 days of venous thromboembolism diagnosis. Immobility in patients with chronic obstructive pulmonary disease is an ominous risk factor for adverse outcomes.</p>
dc.identifier.submissionpathqhs_pp/1025
dc.contributor.departmentMeyers Primary Care Institute
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages1010-8


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