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    Recurrent Plasmodium falciparum malaria infections in Kenyan children diminish T-cell immunity to Epstein Barr virus lytic but not latent antigens

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    Authors
    Snider, Cynthia J.
    Cole, Stephen R.
    Chelimo, Kiprotich
    Sumba, Peter Odada
    Macdonald, Pia D. M.
    John, Chandy C.
    Meshnick, Steven R.
    Moormann, Ann M.
    UMass Chan Affiliations
    Department of Pediatrics
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2012-03-01
    Keywords
    Adolescent
    Burkitt Lymphoma
    CD8-Positive T-Lymphocytes
    Child
    Child, Preschool
    Coinfection
    Enzyme-Linked Immunospot Assay
    Herpesvirus 4, Human
    Humans
    Immunity, Cellular
    Infant
    Interferon-gamma
    Kenya
    Malaria, Falciparum
    Prevalence
    Recurrence
    Epidemiology
    Health Services Research
    Immunology and Infectious Disease
    Parasitic Diseases
    Virus Diseases
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    Abstract
    Plasmodium falciparum malaria (Pf-malaria) and Epstein Barr Virus (EBV) infections coexist in children at risk for endemic Burkitt's lymphoma (eBL); yet studies have only glimpsed the cumulative effect of Pf-malaria on EBV-specific immunity. Using pooled EBV lytic and latent CD8+ T-cell epitope-peptides, IFN-gamma ELISPOT responses were surveyed three times among children (10 months to 15 years) in Kenya from 2002-2004. Prevalence ratios (PR) and 95% confidence intervals (CI) were estimated in association with Pf-malaria exposure, defined at the district-level (Kisumu: holoendemic; Nandi: hypoendemic) and the individual-level. We observed a 46% decrease in positive EBV lytic antigen IFN-gamma responses among 5-9 year olds residing in Kisumu compared to Nandi (PR: 0.54; 95% CI: 0.30-0.99). Individual-level analysis in Kisumu revealed further impairment of EBV lytic antigen responses among 5-9 year olds consistently infected with Pf-malaria compared to those never infected. There were no observed district- or individual-level differences between Pf-malaria exposure and EBV latent antigen IFN-gamma response. The gradual decrease of EBV lytic antigen but not latent antigen IFN-gamma responses after primary infection suggests a specific loss in immunological control over the lytic cycle in children residing in malaria holoendemic areas, further refining our understanding of eBL etiology.
    Source
    PLoS One. 2012;7(3):e31753. Epub 2012 Mar 12. Link to article on publisher's site
    DOI
    10.1371/journal.pone.0031753
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46583
    PubMed ID
    22427806
    Related Resources
    Link to Article in PubMed
    Rights

    Copyright: © 2012 Snider et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0031753
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