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    Health-related quality-of-life findings for the prostate cancer prevention trial

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    Authors
    Moinpour, Carol M.
    Darke, Amy K.
    Donaldson, Gary W.
    Cespedes, Duane
    Johnson, Christine R.
    Ganz, Patricia A.
    Patrick, Donald L.
    Ware, John E. Jr.
    Shumaker, Sally A.
    Meyskens, Frank L.
    Thompson, Ian M. Jr.
    Show allShow less
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2012-09-19
    Keywords
    Quality of Life
    Health Status
    Prostatic Neoplasms
    Epidemiology
    Health Services Research
    Neoplasms
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1093/jnci/djs359
    Abstract
    BACKGROUND: The Prostate Cancer Prevention Trial (PCPT)-a randomized placebo-controlled study of the efficacy of finasteride in preventing prostate cancer-offered the opportunity to prospectively study effects of finasteride and other covariates on the health-related quality of life of participants in a multiyear trial. METHODS: We assessed three health-related quality-of-life domains (measured with the Health Survey Short Form-36: Physical Functioning, Mental Health, and Vitality scales) via questionnaires completed by PCPT participants at enrollment (3 months before randomization), at 6 months after randomization, and annually for 7 years. Covariate data obtained at enrollment from patient-completed questionnaires were included in our model. Mixed-effects model analyses and a cross-sectional presentation at three time points began at 6 months after randomization. All statistical tests were two-sided. RESULTS: For the physical function outcome (n = 16 077), neither the finasteride main effect nor the finasteride interaction with time were statistically significant. The effects of finasteride on physical function were minor and accounted for less than a 1-point difference over time in Physical Functioning scores (mixed-effect estimate = 0.07, 95% confidence interval [CI] = -0.28 to 0.42, P = .71). Comorbidities such as congestive heart failure (estimate = -5.64, 95% CI = -7.96 to -3.32, P < .001), leg pain (estimate = -2.57, 95% CI = -3.04 to -2.10, P < .001), and diabetes (estimate = -1.31, 95% CI = -2.04 to -0.57, P < .001) had statistically significant negative effects on physical function, as did current smoking (estimate = -2.34, 95% CI = -2.97 to -1.71, P < .001) and time on study (estimate = -1.20, 95% CI = -1.36 to -1.03, P < .001). Finasteride did not have a statistically significant effect on the other two dependent variables, mental health and vitality, either in the mixed-effects analyses or in the cross-sectional analysis at any of the three time points. CONCLUSION: Finasteride did not negatively affect SF-36 Physical Functioning, Mental Health, or Vitality scores.
    Source
    J Natl Cancer Inst. 2012 Sep 19;104(18):1373-85. Epub 2012 Sep 12. Link to article on publisher's site
    DOI
    10.1093/jnci/djs359
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46596
    PubMed ID
    22972968
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1093/jnci/djs359
    Scopus Count
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    Population and Quantitative Health Sciences Publications

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