Show simple item record

dc.contributor.authorMoormann, Ann M.
dc.contributor.authorSumba, Peter Odada
dc.contributor.authorChelimo, Kiprotich
dc.contributor.authorFang, Hua (Julia)
dc.contributor.authorTisch, Daniel J.
dc.contributor.authorDent, Arlene E.
dc.contributor.authorJohn, Chandy C.
dc.contributor.authorLong, Carole A.
dc.contributor.authorVulule, John
dc.contributor.authorKazura, James W.
dc.date2022-08-11T08:10:34.000
dc.date.accessioned2022-08-23T17:12:54Z
dc.date.available2022-08-23T17:12:54Z
dc.date.issued2013-07-01
dc.date.submitted2013-04-10
dc.identifier.citation<p>J Infect Dis. 2013 Jul;208(1):149-58. doi: 10.1093/infdis/jit134. <a href="http://dx.doi.org/10.1093/infdis/jit134" target="_blank">Link to article on publisher's site</a></p>
dc.identifier.issn0022-1899 (Linking)
dc.identifier.doi10.1093/infdis/jit134
dc.identifier.pmid23539744
dc.identifier.urihttp://hdl.handle.net/20.500.14038/46605
dc.description.abstractBackground. Acquired immunity to malaria develops with increasing age and repeated infections. Understanding immune correlates of protection from malaria infection would facilitate vaccine development and identification of biomarkers that reflect changes in susceptibility resulting from ongoing malaria control efforts. Methods. The relationship between IgG antibody and IFN-gamma and IL-10 responses to the 42 kD C-terminal fragment of Plasmodium falciparum Merozoite Surface Protein 1 (MSP142) and risk-of-(re)infection were examined following drug-mediated clearance of parasitemia in 94 adults and 95 children in a holoendemic area of western Kenya. Results. Positive IFN-gamma ELISA and ELISPOT responses to MSP-142 3D7 were associated with delayed time-to-(re)infection whereas high-titer IgG antibodies to MSP-142 3D7 or FVO alleles were not independently predictive of risk-of-(re)infection. When IFN-gamma and IL-10 responses were both present, the protective effect of IFN-gamma was abrogated. A Cox proportional hazard model including IFN-gamma, IL-10, MSP142 3D7 IgG antibody responses, hemoglobin S genotype, age and infection status at baseline, showed time to blood-stage infection correlated positively with IFNgamma+ responses and negatively with IL-10+ responses, younger age, and asymptomatic parasitemia. Conclusion. Evaluating combined allele-specific cellular and humoral immunity elicited by malaria provides a more informative measure of protection relative to either measure alone.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23539744&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666139/
dc.subjectMalaria, Falciparum
dc.subjectMerozoite Surface Protein 1
dc.subjectPlasmodium falciparum
dc.subjectImmunity, Humoral
dc.subjectImmunity, Cellular
dc.subjectUMCCTS funding
dc.subjectImmunity
dc.subjectImmunology and Infectious Disease
dc.subjectParasitic Diseases
dc.subjectParasitology
dc.titleHumoral and Cellular Immunity to Plasmodium falciparum Merozoite Surface Protein 1 and Protection from Blood-stage Infection
dc.typeJournal Article
dc.source.journaltitleThe Journal of infectious diseases
dc.source.volume208
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/1069
dc.identifier.contextkey4020072
html.description.abstract<p>Background. Acquired immunity to malaria develops with increasing age and repeated infections. Understanding immune correlates of protection from malaria infection would facilitate vaccine development and identification of biomarkers that reflect changes in susceptibility resulting from ongoing malaria control efforts.</p> <p>Methods. The relationship between IgG antibody and IFN-gamma and IL-10 responses to the 42 kD C-terminal fragment of Plasmodium falciparum Merozoite Surface Protein 1 (MSP142) and risk-of-(re)infection were examined following drug-mediated clearance of parasitemia in 94 adults and 95 children in a holoendemic area of western Kenya.</p> <p>Results. Positive IFN-gamma ELISA and ELISPOT responses to MSP-142 3D7 were associated with delayed time-to-(re)infection whereas high-titer IgG antibodies to MSP-142 3D7 or FVO alleles were not independently predictive of risk-of-(re)infection. When IFN-gamma and IL-10 responses were both present, the protective effect of IFN-gamma was abrogated. A Cox proportional hazard model including IFN-gamma, IL-10, MSP142 3D7 IgG antibody responses, hemoglobin S genotype, age and infection status at baseline, showed time to blood-stage infection correlated positively with IFNgamma+ responses and negatively with IL-10+ responses, younger age, and asymptomatic parasitemia.</p> <p>Conclusion. Evaluating combined allele-specific cellular and humoral immunity elicited by malaria provides a more informative measure of protection relative to either measure alone.</p>
dc.identifier.submissionpathqhs_pp/1069
dc.contributor.departmentDepartment of Pediatrics
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages149-58


This item appears in the following Collection(s)

Show simple item record