Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial
Authors
Pagoto, Sherry L.Schneider, Kristin L.
Whited, Matthew C.
Oleski, Jessica L.
Merriam, Philip A.
Appelhans, Bradley M.
Ma, Yunsheng
Olendzki, Barbara C.
Waring, Molly E.
Busch, A. M.
Lemon, Stephenie C.
Ockene, Ira S.
Crawford, Sybil L.
UMass Chan Affiliations
Department of Medicine, Division of Cardiovascular MedicineDepartment of Medicine, Division of Preventive and Behavioral Medicine
Department of Quantitative Health Sciences
Document Type
Journal ArticlePublication Date
2013-11-01Keywords
ObesityWeight Loss
Depressive Disorder
Behavior Therapy
Comorbidity
UMCCTS funding
Behavior and Behavior Mechanisms
Clinical Epidemiology
Mental and Social Health
Mental Disorders
Nutritional and Metabolic Diseases
Psychiatry and Psychology
Women's Health
Metadata
Show full item recordAbstract
OBJECTIVE:Depression is associated with increased risk for obesity and worse weight loss treatment outcomes. The purpose of the present study was to test the hypothesis that delivering evidence-based behavior therapy for depression before a lifestyle weight loss intervention improves both weight loss and depression. DESIGN:In a randomized controlled trial, obese women with major depressive disorder (N=161, mean age=45.9 (s.d.: 10.8) years) were randomized to brief behavior therapy for depression treatment followed by a lifestyle intervention (BA) or a lifestyle intervention only (LI). Follow-up occurred at 6 and 12 months. Main outcome measures included weight loss and depression symptoms. RESULTS:Intention-to-treat analyses revealed both conditions lost significant weight, but no differences between conditions in weight change at 6 months (BA=-3.0%, s.e.=-0.65%; LI=-3.7%, s.e.=0.63%; P=0.48) or 12 months (BA=-2.6%, s.e.=0.77%; LI=-3.1%, s.e.=0.74%; P=0.72). However, the BA condition evidenced significantly greater improvement in Beck Depression Inventory-II scores relative to the LI condition at both 6 months (BA mean change=-12.5, s.d.=0.85; LI mean change=-9.2, s.d.=0.80, P=0.005) and 12 months (BA mean change=-12.6, s.d.=0.97; LI mean change=-9.9, s.d.=0.93; P=0.045). Participants who experienced depression remission by 6 months (61.2%) lost greater weight (mean=-4.31%; s.e.=0.052) than those who did not (39.7%; mean=-2.47%, s.e.=0.53; P=.001). CONCLUSION:Adding behavior therapy to a lifestyle intervention results in greater depression remission but does not improve weight loss within 1 year. Improvement in depression is associated with greater weight loss.Source
Pagoto S, Schneider KL, Whited MC, Oleski JL, Merriam P, Appelhans B, Ma Y, Olendzki B, Waring ME, Busch AM, Lemon S, Ockene I, Crawford S. Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial. Int J Obes (Lond). 2013 Nov;37(11):1427-34. doi:10.1038/ijo.2013.25. Link to article on publisher's site
DOI
10.1038/ijo.2013.25Permanent Link to this Item
http://hdl.handle.net/20.500.14038/46619PubMed ID
23459323Related Resources
ae974a485f413a2113503eed53cd6c53
10.1038/ijo.2013.25