Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial
AuthorsPagoto, Sherry L.
Schneider, Kristin L.
Whited, Matthew C.
Oleski, Jessica L.
Merriam, Philip A.
Appelhans, Bradley M.
Olendzki, Barbara C.
Waring, Molly E.
Busch, A. M.
Lemon, Stephenie C.
Ockene, Ira S.
Crawford, Sybil L.
UMass Chan AffiliationsDepartment of Medicine, Division of Cardiovascular Medicine
Department of Medicine, Division of Preventive and Behavioral Medicine
Department of Quantitative Health Sciences
Document TypeJournal Article
Behavior and Behavior Mechanisms
Mental and Social Health
Nutritional and Metabolic Diseases
Psychiatry and Psychology
MetadataShow full item record
AbstractOBJECTIVE:Depression is associated with increased risk for obesity and worse weight loss treatment outcomes. The purpose of the present study was to test the hypothesis that delivering evidence-based behavior therapy for depression before a lifestyle weight loss intervention improves both weight loss and depression. DESIGN:In a randomized controlled trial, obese women with major depressive disorder (N=161, mean age=45.9 (s.d.: 10.8) years) were randomized to brief behavior therapy for depression treatment followed by a lifestyle intervention (BA) or a lifestyle intervention only (LI). Follow-up occurred at 6 and 12 months. Main outcome measures included weight loss and depression symptoms. RESULTS:Intention-to-treat analyses revealed both conditions lost significant weight, but no differences between conditions in weight change at 6 months (BA=-3.0%, s.e.=-0.65%; LI=-3.7%, s.e.=0.63%; P=0.48) or 12 months (BA=-2.6%, s.e.=0.77%; LI=-3.1%, s.e.=0.74%; P=0.72). However, the BA condition evidenced significantly greater improvement in Beck Depression Inventory-II scores relative to the LI condition at both 6 months (BA mean change=-12.5, s.d.=0.85; LI mean change=-9.2, s.d.=0.80, P=0.005) and 12 months (BA mean change=-12.6, s.d.=0.97; LI mean change=-9.9, s.d.=0.93; P=0.045). Participants who experienced depression remission by 6 months (61.2%) lost greater weight (mean=-4.31%; s.e.=0.052) than those who did not (39.7%; mean=-2.47%, s.e.=0.53; P=.001). CONCLUSION:Adding behavior therapy to a lifestyle intervention results in greater depression remission but does not improve weight loss within 1 year. Improvement in depression is associated with greater weight loss.
Pagoto S, Schneider KL, Whited MC, Oleski JL, Merriam P, Appelhans B, Ma Y, Olendzki B, Waring ME, Busch AM, Lemon S, Ockene I, Crawford S. Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial. Int J Obes (Lond). 2013 Nov;37(11):1427-34. doi:10.1038/ijo.2013.25. Link to article on publisher's site