Show simple item record

dc.contributor.authorPagoto, Sherry L.
dc.contributor.authorSchneider, Kristin L.
dc.contributor.authorWhited, Matthew C.
dc.contributor.authorOleski, Jessica L.
dc.contributor.authorMerriam, Philip A.
dc.contributor.authorAppelhans, Bradley M.
dc.contributor.authorMa, Yunsheng
dc.contributor.authorOlendzki, Barbara C.
dc.contributor.authorWaring, Molly E.
dc.contributor.authorBusch, A. M.
dc.contributor.authorLemon, Stephenie C.
dc.contributor.authorOckene, Ira S.
dc.contributor.authorCrawford, Sybil L.
dc.date2022-08-11T08:10:34.000
dc.date.accessioned2022-08-23T17:12:58Z
dc.date.available2022-08-23T17:12:58Z
dc.date.issued2013-11-01
dc.date.submitted2013-04-10
dc.identifier.citation<p>Pagoto S, Schneider KL, Whited MC, Oleski JL, Merriam P, Appelhans B, Ma Y, Olendzki B, Waring ME, Busch AM, Lemon S, Ockene I, Crawford S. Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial. Int J Obes (Lond). 2013 Nov;37(11):1427-34. doi:10.1038/ijo.2013.25. <a href="http://dx.doi.org/10.1038/ijo.2013.25" target="_blank">Link to article on publisher's site</a></p>
dc.identifier.issn0307-0565 (Linking)
dc.identifier.doi10.1038/ijo.2013.25
dc.identifier.pmid23459323
dc.identifier.urihttp://hdl.handle.net/20.500.14038/46619
dc.description.abstractOBJECTIVE:Depression is associated with increased risk for obesity and worse weight loss treatment outcomes. The purpose of the present study was to test the hypothesis that delivering evidence-based behavior therapy for depression before a lifestyle weight loss intervention improves both weight loss and depression. DESIGN:In a randomized controlled trial, obese women with major depressive disorder (N=161, mean age=45.9 (s.d.: 10.8) years) were randomized to brief behavior therapy for depression treatment followed by a lifestyle intervention (BA) or a lifestyle intervention only (LI). Follow-up occurred at 6 and 12 months. Main outcome measures included weight loss and depression symptoms. RESULTS:Intention-to-treat analyses revealed both conditions lost significant weight, but no differences between conditions in weight change at 6 months (BA=-3.0%, s.e.=-0.65%; LI=-3.7%, s.e.=0.63%; P=0.48) or 12 months (BA=-2.6%, s.e.=0.77%; LI=-3.1%, s.e.=0.74%; P=0.72). However, the BA condition evidenced significantly greater improvement in Beck Depression Inventory-II scores relative to the LI condition at both 6 months (BA mean change=-12.5, s.d.=0.85; LI mean change=-9.2, s.d.=0.80, P=0.005) and 12 months (BA mean change=-12.6, s.d.=0.97; LI mean change=-9.9, s.d.=0.93; P=0.045). Participants who experienced depression remission by 6 months (61.2%) lost greater weight (mean=-4.31%; s.e.=0.052) than those who did not (39.7%; mean=-2.47%, s.e.=0.53; P=.001). CONCLUSION:Adding behavior therapy to a lifestyle intervention results in greater depression remission but does not improve weight loss within 1 year. Improvement in depression is associated with greater weight loss.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23459323&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675166/
dc.subjectObesity
dc.subjectWeight Loss
dc.subjectDepressive Disorder
dc.subjectBehavior Therapy
dc.subjectComorbidity
dc.subjectUMCCTS funding
dc.subjectBehavior and Behavior Mechanisms
dc.subjectClinical Epidemiology
dc.subjectMental and Social Health
dc.subjectMental Disorders
dc.subjectNutritional and Metabolic Diseases
dc.subjectPsychiatry and Psychology
dc.subjectWomen's Health
dc.titleRandomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial
dc.typeJournal Article
dc.source.journaltitleInternational journal of obesity (2005)
dc.source.volume37
dc.source.issue11
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/1081
dc.identifier.contextkey4020084
html.description.abstract<p>OBJECTIVE:Depression is associated with increased risk for obesity and worse weight loss treatment outcomes. The purpose of the present study was to test the hypothesis that delivering evidence-based behavior therapy for depression before a lifestyle weight loss intervention improves both weight loss and depression.</p> <p>DESIGN:In a randomized controlled trial, obese women with major depressive disorder (N=161, mean age=45.9 (s.d.: 10.8) years) were randomized to brief behavior therapy for depression treatment followed by a lifestyle intervention (BA) or a lifestyle intervention only (LI). Follow-up occurred at 6 and 12 months. Main outcome measures included weight loss and depression symptoms.</p> <p>RESULTS:Intention-to-treat analyses revealed both conditions lost significant weight, but no differences between conditions in weight change at 6 months (BA=-3.0%, s.e.=-0.65%; LI=-3.7%, s.e.=0.63%; P=0.48) or 12 months (BA=-2.6%, s.e.=0.77%; LI=-3.1%, s.e.=0.74%; P=0.72). However, the BA condition evidenced significantly greater improvement in Beck Depression Inventory-II scores relative to the LI condition at both 6 months (BA mean change=-12.5, s.d.=0.85; LI mean change=-9.2, s.d.=0.80, P=0.005) and 12 months (BA mean change=-12.6, s.d.=0.97; LI mean change=-9.9, s.d.=0.93; P=0.045). Participants who experienced depression remission by 6 months (61.2%) lost greater weight (mean=-4.31%; s.e.=0.052) than those who did not (39.7%; mean=-2.47%, s.e.=0.53; P=.001).</p> <p>CONCLUSION:Adding behavior therapy to a lifestyle intervention results in greater depression remission but does not improve weight loss within 1 year. Improvement in depression is associated with greater weight loss.</p>
dc.identifier.submissionpathqhs_pp/1081
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages1427-34


This item appears in the following Collection(s)

Show simple item record