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    Correlation of trabeculae and papillary muscles with clinical and cardiac characteristics and impact on cmr measures of LV anatomy and function

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    Authors
    Chuang, Michael L.
    Gona, Philimon
    Hautvast, Gilion L.T.F.
    Salton, Carol J.
    Blease, Susan J.
    Yeon, Susan B.
    Breeuwer, Marcel
    O'Donnell, Christopher J.
    Manning, Warren J.
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2012-11-01
    Keywords
    Bioinformatics
    Biostatistics
    Cardiology
    Cardiovascular Diseases
    Clinical Epidemiology
    Health Services Research
    Public Health
    
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    http://dx.doi.org/10.1016/j.jcmg.2012.05.015
    Abstract
    OBJECTIVES: The goal of this study was to assess the relationship of left ventricular (LV) trabeculae and papillary muscles (TPM) with clinical characteristics in a community-based, free-living adult cohort and to determine the effect of TPM on quantitative measures of LV volume, mass, and ejection fraction (EF). BACKGROUND: Hypertrabeculation has been associated with adverse cardiovascular events, but the distribution and clinical correlates of the volume and mass of the TPM in a normal left ventricle have not been well characterized. METHODS: Short-axis cine cardiac magnetic resonance images, obtained using a steady-state free precession sequence from 1,494 members of the Framingham Heart Study Offspring cohort, were analyzed with software that automatically segments TPM. Absolute TPM volume, TPM as a fraction of end-diastolic volume (EDV) (TPM/EDV), and TPM mass as a fraction of LV mass were determined in all offspring and in a referent group of offspring free of clinical cardiovascular disease and hypertension. RESULTS: In the referent group (mean age 61 +/- 9 years; 262 men and 423 women), mean TPM was 23 +/- 3% of LV EDV in both sexes (p = 0.9). TPM/EDV decreased with age (p < 0.02) but was not associated with body mass index. TPM mass as a fraction of LV mass was inversely correlated with age (p < 0.0001), body mass index (p < 0.018), and systolic blood pressure (p < 0.0001). Among all 1,494 participants (699 men), LV volumes decreased 23%, LV mass increased 28%, and EF increased by 7.5 EF units (p < 0.0001) when TPM were considered myocardial mass rather than part of the LV blood pool. CONCLUSIONS: Global cardiac magnetic resonance LV parameters were significantly affected by whether TPM was considered as part of the LV blood pool or as part of LV mass. Our cross-sectional data from a healthy referent group of adults free of clinical cardiovascular disease demonstrated that TPM/EDV decreases with increasing age in both sexes but is not related to hypertension or obesity. Elsevier Inc. All rights reserved.
    Source
    JACC Cardiovasc Imaging. 2012 Nov;5(11):1115-23. doi: 10.1016/j.jcmg.2012.05.015. Link to article on publisher's site
    DOI
    10.1016/j.jcmg.2012.05.015
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46642
    PubMed ID
    23153911
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jcmg.2012.05.015
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