Correlation of trabeculae and papillary muscles with clinical and cardiac characteristics and impact on cmr measures of LV anatomy and function
dc.contributor.author | Chuang, Michael L. | |
dc.contributor.author | Gona, Philimon | |
dc.contributor.author | Hautvast, Gilion L.T.F. | |
dc.contributor.author | Salton, Carol J. | |
dc.contributor.author | Blease, Susan J. | |
dc.contributor.author | Yeon, Susan B. | |
dc.contributor.author | Breeuwer, Marcel | |
dc.contributor.author | O'Donnell, Christopher J. | |
dc.contributor.author | Manning, Warren J. | |
dc.date | 2022-08-11T08:10:34.000 | |
dc.date.accessioned | 2022-08-23T17:13:04Z | |
dc.date.available | 2022-08-23T17:13:04Z | |
dc.date.issued | 2012-11-01 | |
dc.date.submitted | 2013-04-10 | |
dc.identifier.citation | JACC Cardiovasc Imaging. 2012 Nov;5(11):1115-23. doi: 10.1016/j.jcmg.2012.05.015. <a href="http://dx.doi.org/10.1016/j.jcmg.2012.05.015">Link to article on publisher's site</a> | |
dc.identifier.issn | 1876-7591 (Electronic) | |
dc.identifier.doi | 10.1016/j.jcmg.2012.05.015 | |
dc.identifier.pmid | 23153911 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/46642 | |
dc.description.abstract | OBJECTIVES: The goal of this study was to assess the relationship of left ventricular (LV) trabeculae and papillary muscles (TPM) with clinical characteristics in a community-based, free-living adult cohort and to determine the effect of TPM on quantitative measures of LV volume, mass, and ejection fraction (EF). BACKGROUND: Hypertrabeculation has been associated with adverse cardiovascular events, but the distribution and clinical correlates of the volume and mass of the TPM in a normal left ventricle have not been well characterized. METHODS: Short-axis cine cardiac magnetic resonance images, obtained using a steady-state free precession sequence from 1,494 members of the Framingham Heart Study Offspring cohort, were analyzed with software that automatically segments TPM. Absolute TPM volume, TPM as a fraction of end-diastolic volume (EDV) (TPM/EDV), and TPM mass as a fraction of LV mass were determined in all offspring and in a referent group of offspring free of clinical cardiovascular disease and hypertension. RESULTS: In the referent group (mean age 61 +/- 9 years; 262 men and 423 women), mean TPM was 23 +/- 3% of LV EDV in both sexes (p = 0.9). TPM/EDV decreased with age (p < 0.02) but was not associated with body mass index. TPM mass as a fraction of LV mass was inversely correlated with age (p < 0.0001), body mass index (p < 0.018), and systolic blood pressure (p < 0.0001). Among all 1,494 participants (699 men), LV volumes decreased 23%, LV mass increased 28%, and EF increased by 7.5 EF units (p < 0.0001) when TPM were considered myocardial mass rather than part of the LV blood pool. CONCLUSIONS: Global cardiac magnetic resonance LV parameters were significantly affected by whether TPM was considered as part of the LV blood pool or as part of LV mass. Our cross-sectional data from a healthy referent group of adults free of clinical cardiovascular disease demonstrated that TPM/EDV decreases with increasing age in both sexes but is not related to hypertension or obesity. Elsevier Inc. All rights reserved. | |
dc.language.iso | en_US | |
dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23153911&dopt=Abstract">Link to Article in PubMed</a> | |
dc.relation.url | http://dx.doi.org/10.1016/j.jcmg.2012.05.015 | |
dc.subject | Bioinformatics | |
dc.subject | Biostatistics | |
dc.subject | Cardiology | |
dc.subject | Cardiovascular Diseases | |
dc.subject | Clinical Epidemiology | |
dc.subject | Health Services Research | |
dc.subject | Public Health | |
dc.title | Correlation of trabeculae and papillary muscles with clinical and cardiac characteristics and impact on cmr measures of LV anatomy and function | |
dc.type | Journal Article | |
dc.source.journaltitle | JACC. Cardiovascular imaging | |
dc.source.volume | 5 | |
dc.source.issue | 11 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/qhs_pp/1102 | |
dc.identifier.contextkey | 4020105 | |
html.description.abstract | <p>OBJECTIVES: The goal of this study was to assess the relationship of left ventricular (LV) trabeculae and papillary muscles (TPM) with clinical characteristics in a community-based, free-living adult cohort and to determine the effect of TPM on quantitative measures of LV volume, mass, and ejection fraction (EF).</p> <p>BACKGROUND: Hypertrabeculation has been associated with adverse cardiovascular events, but the distribution and clinical correlates of the volume and mass of the TPM in a normal left ventricle have not been well characterized.</p> <p>METHODS: Short-axis cine cardiac magnetic resonance images, obtained using a steady-state free precession sequence from 1,494 members of the Framingham Heart Study Offspring cohort, were analyzed with software that automatically segments TPM. Absolute TPM volume, TPM as a fraction of end-diastolic volume (EDV) (TPM/EDV), and TPM mass as a fraction of LV mass were determined in all offspring and in a referent group of offspring free of clinical cardiovascular disease and hypertension.</p> <p>RESULTS: In the referent group (mean age 61 +/- 9 years; 262 men and 423 women), mean TPM was 23 +/- 3% of LV EDV in both sexes (p = 0.9). TPM/EDV decreased with age (p < 0.02) but was not associated with body mass index. TPM mass as a fraction of LV mass was inversely correlated with age (p < 0.0001), body mass index (p < 0.018), and systolic blood pressure (p < 0.0001). Among all 1,494 participants (699 men), LV volumes decreased 23%, LV mass increased 28%, and EF increased by 7.5 EF units (p < 0.0001) when TPM were considered myocardial mass rather than part of the LV blood pool.</p> <p>CONCLUSIONS: Global cardiac magnetic resonance LV parameters were significantly affected by whether TPM was considered as part of the LV blood pool or as part of LV mass. Our cross-sectional data from a healthy referent group of adults free of clinical cardiovascular disease demonstrated that TPM/EDV decreases with increasing age in both sexes but is not related to hypertension or obesity. Elsevier Inc. All rights reserved.</p> | |
dc.identifier.submissionpath | qhs_pp/1102 | |
dc.contributor.department | Department of Quantitative Health Sciences | |
dc.source.pages | 1115-23 |