Atomoxetine increases fronto-parietal functional MRI activation in attention-deficit/hyperactivity disorder: a pilot study
Shin, Lisa M.
Mick, Eric O.
Seidman, Larry J.
UMass Chan AffiliationsDepartment of Quantitative Health Sciences
Document TypeJournal Article
KeywordsBehavioral Disciplines and Activities
Bioimaging and Biomedical Optics
Pharmacy and Pharmaceutical Sciences
Psychiatry and Psychology
MetadataShow full item record
AbstractWe hypothesized that atomoxetine (ATMX) would produce similar brain effects in attention-deficit/hyperactivity disorder (ADHD) as those of methylphenidate (MPH). Eleven ADHD adults performed the Multi-Source Interference Task (MSIT) during functional magnetic resonance imaging (fMRI) at baseline and after 6 weeks of ATMX treatment. ATMX was associated with increased fMRI activation of dorsolateral prefrontal cortex, parietal cortex and cerebellum but not dorsal anterior midcingulate cortex (daMCC). These results suggest that ATMX and MPH have similar but not identical brain effects.
SourceEpub 2012 Nov 10. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/46645
Related ResourcesLink to Article in PubMed