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dc.contributor.authorLynch, Shaina M.
dc.contributor.authorWilson, Sarah M.
dc.contributor.authorDeRycke, Eric C.
dc.contributor.authorDriscoll, Mary A.
dc.contributor.authorBecker, William C.
dc.contributor.authorGoulet, Joseph L.
dc.contributor.authorKerns, Robert D.
dc.contributor.authorMattocks, Kristin M.
dc.contributor.authorBrandt, Cynthia A.
dc.contributor.authorBathulapalli, Harini
dc.contributor.authorSkanderson, Melissa
dc.contributor.authorHaskell, Sally G.
dc.contributor.authorBastian, Lori A.
dc.date2022-08-11T08:10:35.000
dc.date.accessioned2022-08-23T17:13:37Z
dc.date.available2022-08-23T17:13:37Z
dc.date.issued2018-09-01
dc.date.submitted2018-11-08
dc.identifier.citation<p>Pain Med. 2018 Sep 1;19(suppl_1):S5-S11. doi: 10.1093/pm/pny146. <a href="https://doi.org/10.1093/pm/pny146">Link to article on publisher's site</a></p>
dc.identifier.issn1526-2375 (Linking)
dc.identifier.doi10.1093/pm/pny146
dc.identifier.pmid30203017
dc.identifier.urihttp://hdl.handle.net/20.500.14038/46768
dc.description.abstractObjective: Chronic pain is a significant problem in patients living with hepatitis C virus (HCV). Tobacco smoking is an independent risk factor for high pain intensity among veterans. This study aims to examine the independent associations with smoking and HCV on pain intensity, as well as the interaction of smoking and HCV on the association with pain intensity. Design/Particpants: Cross-sectional analysis of a cohort study of veterans of Operations Enduring Freedom/Iraqi Freedom/New Dawn (OEF/OIF/OND) who had at least one visit to a Veterans Health Administration (VHA) primary care clinic between 2001 and 2014. Methods: HCV was identified using ICD-9 codes from electronic medical records (EMRs). Pain intensity, reported on a 0-10 numeric rating scale, was categorized as none/mild (0-3) and moderate/severe (4-10). Results: Among 654,841 OEF/OIF/OND veterans (median age [interquartile range] = 26 [23-36] years), 2,942 (0.4%) were diagnosed with HCV. Overall, moderate/severe pain intensity was reported in 36% of veterans, and 37% were current smokers. The adjusted odds of reporting moderate/severe pain intensity were 1.23 times higher (95% confidence interval [CI] = 1.14-1.33) for those with HCV and 1.26 times higher (95% CI = 1.25-1.28) for current smokers. In the interaction model, there was a significant Smoking Status x HCV interaction (P = 0.03). Among veterans with HCV, smoking had a significantly larger association with moderate/severe pain (adjusted odds ratio [OR] = 1.50, P < 0.001) than among veterans without HCV (adjusted OR = 1.26, P < 0.001). Conclusions: We found that current smoking is more strongly linked to pain intensity among veterans with HCV. Further investigations are needed to explore the impact of smoking status on pain and to promote smoking cessation and pain management in veterans with HCV.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=30203017&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rights2018 American Academy of Pain Medicine. This work is written by US Government employees and is in the public domain in the US.
dc.subjectHepatitis C
dc.subjectSmoking
dc.subjectVeterans
dc.subjectTobacco
dc.subjectPain
dc.subjectsmoking
dc.subjectpain
dc.subjectveterans
dc.subjecthepatitis c virus
dc.subjectcigarette smoking
dc.subjectBehavioral Medicine
dc.subjectBehavior and Behavior Mechanisms
dc.subjectHealth Services Research
dc.subjectMilitary and Veterans Studies
dc.subjectPain Management
dc.subjectPathological Conditions, Signs and Symptoms
dc.subjectVirus Diseases
dc.titleImpact of Cigarette Smoking Status on Pain Intensity Among Veterans With and Without Hepatitis C
dc.typeJournal Article
dc.source.journaltitlePain medicine (Malden, Mass.)
dc.source.volume19
dc.source.issuesuppl_1
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2229&amp;context=qhs_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/1228
dc.identifier.contextkey13269252
refterms.dateFOA2022-08-23T17:13:37Z
html.description.abstract<p>Objective: Chronic pain is a significant problem in patients living with hepatitis C virus (HCV). Tobacco smoking is an independent risk factor for high pain intensity among veterans. This study aims to examine the independent associations with smoking and HCV on pain intensity, as well as the interaction of smoking and HCV on the association with pain intensity.</p> <p>Design/Particpants: Cross-sectional analysis of a cohort study of veterans of Operations Enduring Freedom/Iraqi Freedom/New Dawn (OEF/OIF/OND) who had at least one visit to a Veterans Health Administration (VHA) primary care clinic between 2001 and 2014.</p> <p>Methods: HCV was identified using ICD-9 codes from electronic medical records (EMRs). Pain intensity, reported on a 0-10 numeric rating scale, was categorized as none/mild (0-3) and moderate/severe (4-10).</p> <p>Results: Among 654,841 OEF/OIF/OND veterans (median age [interquartile range] = 26 [23-36] years), 2,942 (0.4%) were diagnosed with HCV. Overall, moderate/severe pain intensity was reported in 36% of veterans, and 37% were current smokers. The adjusted odds of reporting moderate/severe pain intensity were 1.23 times higher (95% confidence interval [CI] = 1.14-1.33) for those with HCV and 1.26 times higher (95% CI = 1.25-1.28) for current smokers. In the interaction model, there was a significant Smoking Status x HCV interaction (P = 0.03). Among veterans with HCV, smoking had a significantly larger association with moderate/severe pain (adjusted odds ratio [OR] = 1.50, P < 0.001) than among veterans without HCV (adjusted OR = 1.26, P < 0.001).</p> <p>Conclusions: We found that current smoking is more strongly linked to pain intensity among veterans with HCV. Further investigations are needed to explore the impact of smoking status on pain and to promote smoking cessation and pain management in veterans with HCV.</p>
dc.identifier.submissionpathqhs_pp/1228
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pagesS5-S11


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