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    Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data

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    Authors
    Tylee, Daniel S.
    Mick, Eric O.
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2018-10-16
    Keywords
    C-reactive protein
    Crohn's disease
    Tourette syndrome
    allergy
    anorexia nervosa
    attention deficit-hyperactivity disorder
    autoimmune disorder
    bipolar disorder
    celiac disease
    childhood ear infection
    genetic correlation
    genome-wide association
    hypothyroidism
    major depression
    neuroticism
    obsessive schizophrenia
    primary biliary cirrhosis
    rheumatoid arthritis
    smoking
    systemic lupus erythematosus
    tuberculosis susceptibility
    type 1 diabetes
    ulcerative colitis
    Genetics and Genomics
    Immune System Diseases
    Medical Genetics
    Mental Disorders
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    Link to Full Text
    https://doi.org/10.1002/ajmg.b.32652
    Abstract
    Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and altered immune signaling. It is unclear whether these altered immunological states have a shared genetic basis with those psychiatric disorders. The present study sought to use existing summary-level data from previous genome-wide association studies to determine if commonly varying single nucleotide polymorphisms are shared between psychiatric and immune-related phenotypes. We estimated heritability and examined pair-wise genetic correlations using the linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics methods. Using LDSC, we observed significant genetic correlations between immune-related disorders and several psychiatric disorders, including anorexia nervosa, attention deficit-hyperactivity disorder, bipolar disorder, major depression, obsessive compulsive disorder, schizophrenia, smoking behavior, and Tourette syndrome. Loci significantly mediating genetic correlations were identified for schizophrenia when analytically paired with Crohn's disease, primary biliary cirrhosis, systemic lupus erythematosus, and ulcerative colitis. We report significantly correlated loci and highlight those containing genome-wide associations and candidate genes for respective disorders. We also used the LDSC method to characterize genetic correlations among the immune-related phenotypes. We discuss our findings in the context of relevant genetic and epidemiological literature, as well as the limitations and caveats of the study.
    Source

    Am J Med Genet B Neuropsychiatr Genet. 2018 Oct;177(7):641-657. doi: 10.1002/ajmg.b.32652. Epub 2018 Oct 16. Link to article on publisher's site

    DOI
    10.1002/ajmg.b.32652
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46771
    PubMed ID
    30325587
    Notes

    Full author list omitted for brevity. For the full list of authors, see article.

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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1002/ajmg.b.32652
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