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    Adjuvant Use and the Intensification of Pharmacologic Management for Pain in Nursing Home Residents with Cancer: Data from a US National Database

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    Authors
    Liu, Shao-Hsien
    Hunnicutt, Jacob N.
    Ulbricht, Christine M.
    Dube, Catherine E.
    Hume, Anne L.
    Lapane, Kate L.
    UMass Chan Affiliations
    Division of Epidemiology of Chronic Diseases and Vulnerable Populations, Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2019-06-01
    Keywords
    Clinical Epidemiology
    Epidemiology
    Geriatrics
    Health Services Research
    Medical Pharmacology
    Neoplasms
    Pain Management
    Pharmaceutical Preparations
    Therapeutics
    
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    Link to Full Text
    https://doi.org/10.1007/s40266-019-00650-3
    Abstract
    OBJECTIVES: Our objective was to describe the prevalence of adjuvants to opioid therapy and changes in these agents for pharmacologic management in nursing home residents with cancer. METHODS: We included Medicare beneficiaries with cancer and documented opioid use at nursing home admission in 2011-2013 (N = 3268). The Minimum Data Set 3.0 provided information on sociodemographic and clinical characteristics. Part D claims provided information on opioid and adjuvant use during the 7 days after admission and 90 days later. Proportions of changes in these agents were estimated. Separate logistic models estimated associations between resident characteristics and (1) use of adjuvants at admission and (2) intensification of pharmacologic management at 90 days. RESULTS: Nearly 20% of patients received adjuvants to opioids at admission, with gabapentin the most common adjuvant (34.4%). After 90 days, approximately 25% had maintained or intensified pharmacologic management. While advanced age ( > /= 85 vs. 65-74 years, adjusted odds ratio [aOR] 0.80; 95% confidence interval [CI] 0.63-1.02) and comorbidities, including dementia (aOR 0.65; 95% CI 0.53-0.82) and depression (aOR 1.55; 95% CI 1.29-1.87), were associated with adjuvant use at admission, worse cognitive impairment (severe vs. no/mild, aOR 0.80; 95% CI 0.64-0.99) and presence of more severe pain (moderate/severe vs. no pain, aOR 1.60; 95% CI 1.26-2.03) were associated with intensification of drug regimen. CONCLUSION: Given aging-related changes and the presence of comorbid conditions in older adults, safety studies of these practices are warranted.
    Source

    Drugs Aging. 2019 Jun;36(6):549-557. doi: 10.1007/s40266-019-00650-3. Link to article on publisher's site

    DOI
    10.1007/s40266-019-00650-3
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46791
    PubMed ID
    30924097
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1007/s40266-019-00650-3
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