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dc.contributor.authorKim, Jang-Rak
dc.contributor.authorKiefe, Catarina I.
dc.contributor.authorLiu, K.
dc.contributor.authorWilliams, O. Dale
dc.contributor.authorJacobs, David R.
dc.contributor.authorOberman, Albert
dc.date2022-08-11T08:10:35.000
dc.date.accessioned2022-08-23T17:13:50Z
dc.date.available2022-08-23T17:13:50Z
dc.date.issued1999-02-19
dc.date.submitted2010-04-27
dc.identifier.citationHypertension. 1999 Feb;33(2):640-6.
dc.identifier.issn0194-911X (Linking)
dc.identifier.pmid10024320
dc.identifier.urihttp://hdl.handle.net/20.500.14038/46821
dc.description.abstractThe objective of the present study was to examine the hypothesis that baseline heart rate (HR) predicts subsequent blood pressure (BP) independently of baseline BP. In the multicenter longitudinal Coronary Artery Risk Development in Young Adults study of black and white men and women initially aged 18 to 30 years, we studied 4762 participants who were not current users of antihypertensive drugs and had no history of heart problems at the baseline examination (1985-1986). In each race-sex subgroup, we estimated the effect of baseline HR on BP 2, 5, 7, and 10 years later by use of repeated measures regression analysis, adjusting for baseline BP, age, education, body fatness, physical fitness, fasting insulin, parental hypertension, cigarette smoking, alcohol consumption, oral contraceptive use, and change of body mass index from baseline. The association between baseline HR and subsequent systolic BP (SBP) was explained by multivariable adjustment. However, HR was an independent predictor of subsequent diastolic BP (DBP) regardless of initial BP and other confounders in white men, white women, and black men (0.7 mm Hg increase per 10 bpm). We incorporated the part of the association that was already present at baseline by not adjusting for baseline DBP: the mean increase in subsequent DBP was 1.3 mm Hg per 10 bpm in white men, white women, and black men. A high HR may be considered a risk factor for subsequent high DBP in young persons.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=10024320&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://hyper.ahajournals.org/cgi/content/abstract/33/2/640
dc.subjectAdolescent
dc.subjectAdult
dc.subject*African Continental Ancestry Group
dc.subjectBlood Pressure
dc.subject*European Continental Ancestry Group
dc.subjectFemale
dc.subjectHeart Rate
dc.subjectHumans
dc.subjectMale
dc.subjectMultivariate Analysis
dc.subjectSex Factors
dc.subjectBioinformatics
dc.subjectBiostatistics
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.titleHeart rate and subsequent blood pressure in young adults: the CARDIA study
dc.typeJournal Article
dc.source.journaltitleHypertension
dc.source.volume33
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/129
dc.identifier.contextkey1287874
html.description.abstract<p>The objective of the present study was to examine the hypothesis that baseline heart rate (HR) predicts subsequent blood pressure (BP) independently of baseline BP. In the multicenter longitudinal Coronary Artery Risk Development in Young Adults study of black and white men and women initially aged 18 to 30 years, we studied 4762 participants who were not current users of antihypertensive drugs and had no history of heart problems at the baseline examination (1985-1986). In each race-sex subgroup, we estimated the effect of baseline HR on BP 2, 5, 7, and 10 years later by use of repeated measures regression analysis, adjusting for baseline BP, age, education, body fatness, physical fitness, fasting insulin, parental hypertension, cigarette smoking, alcohol consumption, oral contraceptive use, and change of body mass index from baseline. The association between baseline HR and subsequent systolic BP (SBP) was explained by multivariable adjustment. However, HR was an independent predictor of subsequent diastolic BP (DBP) regardless of initial BP and other confounders in white men, white women, and black men (0.7 mm Hg increase per 10 bpm). We incorporated the part of the association that was already present at baseline by not adjusting for baseline DBP: the mean increase in subsequent DBP was 1.3 mm Hg per 10 bpm in white men, white women, and black men. A high HR may be considered a risk factor for subsequent high DBP in young persons.</p>
dc.identifier.submissionpathqhs_pp/129
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages640-6


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