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    Increased platelet activation and fibrinogen in Asian Indians. Potential implications for coronary risk

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    Authors
    Markovitz, Jerome H.
    Kulkarni, K.
    Goldschmidt-Clermont, P.
    Kiefe, Catarina I.
    Rustagi, P.
    Sekar, Padmini
    Nanda, N.
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    1998-08-26
    Keywords
    Adult
    Coronary Disease
    Cross-Cultural Comparison
    Female
    Fibrinogen
    Humans
    India
    Male
    Middle Aged
    Platelet Activation
    Risk Factors
    Bioinformatics
    Biostatistics
    Epidemiology
    Health Services Research
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    Link to Full Text
    http://dx.doi.org/10.1053/euhj.1997.0800
    Abstract
    AIMS: To determine whether Asian Indians (Indians), a group known to have high rates of coronary heart disease, have increased platelet activation and fibrinogen levels relative to white Americans of European origin (whites). METHODS AND RESULTS: Forty healthy, non-smoking Indians, aged 25-45, were matched with 40 healthy whites for age (within 3 years) and gender. Platelet activation was tested in blood exiting a bleeding time wound at 1 and 2 min post-incision (wound-induced activation), as well as in venous blood stimulated in vitro with collagen, using whole blood flow cytometry. Other risk factors, including fibrinogen levels, family history of diabetes or coronary heart disease, fasting insulin and lipid levels, and Lp(a) were also assessed. Fibrinogen levels were higher among Indians than whites, even after adjustment for gender or family history of coronary heart disease (P < 0.05). Indians had higher levels of wound-induced glycoprotein IIb/IIIa binding and platelet secretion (P-selectin expression) than whites, with the greatest differences found when comparing the upper quintile of activation for each group (Ps < 0.05). Indians with a family history of coronary heart disease (n = 15) had higher levels of platelet secretion (wound-induced and in vitro) than Indians without a family history (Ps < 0.05), while the relationship was reversed among whites. Platelet activation measures were not consistently related to other coronary risk factors, while fibrinogen was related to triglyceride and insulin levels among Indians. CONCLUSION: Indians have elevated fibrinogen and platelet activation levels relative to whites. These factors may contribute to the increased coronary risk observed in Indians.
    Source
    Eur Heart J. 1998 May;19(5):720-6.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/46930
    PubMed ID
    9717004
    Related Resources
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    Population and Quantitative Health Sciences Publications

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