Prospective association between C-reactive protein and fatigue in the coronary artery risk development in young adults study
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UMass Chan Affiliations
Department of Quantitative Health SciencesDocument Type
Journal ArticlePublication Date
2009-07-31Keywords
AdolescentAdult
African Americans
Age Factors
Biological Markers
C-Reactive Protein
European Continental Ancestry Group
Fatigue
Female
Humans
Inflammation
Longitudinal Studies
Male
Middle Aged
*Population Surveillance
Risk Factors
Bioinformatics
Biostatistics
Epidemiology
Health Services Research
Metadata
Show full item recordAbstract
BACKGROUND: Fatigue is highly prevalent and causes serious disruption in quality of life. Although the underlying biological mechanism is unknown, increases in inflammation have been implicated. This prospective study examined the association between C-reactive protein (CRP), a biomarker of systemic inflammation, and fatigue 5 years later. METHODS: The Coronary Artery Risk Development in Young Adults (CARDIA) study is a population-based longitudinal study conducted in four U.S. cities. Highly sensitive CRP concentration and fatigue were measured in 2983 African American and white adults at both year 15 (2000-2001, ages 33-45 years) and year 20 (2005-2006) examinations. Fatigue was assessed using the vitality subscale of the 12-item Short Form Health Survey. RESULTS: Plasma CRP concentration at baseline (i.e., CARDIA year 15) was a significant predictor of fatigue level 5 years later (unadjusted beta = .126, p < .001). After adjustment for potential confounders, this association remained significant (adjusted beta = .044, p = .033). Additionally, baseline CRP independently predicted fatigue in the subgroup of participants without medical comorbidity (adjusted beta = .051, p = .039). Fatigue was associated with a persistent elevation of CRP at both examinations but not with a transient elevation of CRP at only one of the examinations. CONCLUSIONS: This is the first study to demonstrate a prospective association between an inflammatory marker and fatigue in a general population. Furthermore, the association between low-grade systemic inflammation and fatigue seems primarily driven by persistent immune activation and not explained by the presence or development of medical comorbidity.Source
Biol Psychiatry. 2009 Nov 1;66(9):871-8. Epub 2009 Jul 29. Link to article on publisher's siteDOI
10.1016/j.biopsych.2009.06.008Permanent Link to this Item
http://hdl.handle.net/20.500.14038/47021PubMed ID
19640510Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.biopsych.2009.06.008