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    Baseline characteristics, management practices, and in-hospital outcomes of patients hospitalized with acute coronary syndromes in the Global Registry of Acute Coronary Events (GRACE)

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    Authors
    Steg, Phillippe Gabriel
    Goldberg, Robert J.
    Gore, Joel M.
    Fox, Keith A. A.
    Eagle, Kim A.
    Flather, Marcus
    Sadiq, Immad
    Kasper, Rachel
    Rushton-Mellor, Sophie K.
    Anderson, Frederick A.
    UMass Chan Affiliations
    Department of Medicine, Division of Cardiovascular Medicine
    Document Type
    Journal Article
    Publication Date
    2002-08-06
    Keywords
    Aged
    Analysis of Variance
    *Angina, Unstable
    Female
    Hospital Mortality
    Hospitalization
    Humans
    Male
    Middle Aged
    *Myocardial Infarction
    Syndrome
    Treatment Outcome
    Bioinformatics
    Biostatistics
    Epidemiology
    Health Services Research
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    Link to Full Text
    http://dx.doi.org/10.1016/S0002-9149(02)02489-X
    Abstract
    Acute coronary syndrome (ACS) represents a heterogenous spectrum of conditions. The Global Registry of Acute Coronary Events (GRACE) describes the epidemiology, management, and outcomes of patients with ACS. Data were collected from 11,543 patients enrolled in 14 countries. Of these patients, 30% had ST-segment elevation myocardial infarction (STEMI), 25% had non-ST-segment elevation myocardial infarction (NSTEMI), 38% had unstable angina pectoris, and 7% had other cardiac or noncardiac diagnoses. Over half of these patients (53%) were >/=65 years old. Reperfusion therapy was used in 62% of patients with STEMI. Percutaneous coronary intervention was performed in 40% of these subjects during the index admission. Intravenous glycoprotein IIb/IIIa blockers were used in 23%, 20%, and 7% of patients with STEMI, NSTEMI, and unstable angina, respectively (STEMI vs NSTEMI, p = 0.0018, and for either group vs unstable angina, p <0.001). Coronary artery bypass grafting was performed in 4%, 10%, and 5% of patients, respectively (p <0.0001). Hospital case fatality rates were markedly different among patients with STEMI, NSTEMI, and unstable angina (7%, 6%, and 3%, respectively; STEMI vs NSTEMI, p = 0.0459, and for either group vs unstable angina, p <0.001). Congestive heart failure complicated the hospital course in 18%, 18%, and 10% of the patients, respectively (p <0.0001), and recurrent angina with ST-segment changes occurred before discharge in 10%, 10%, and 9% of patients, respectively (p = 0.2644). GRACE provides a detailed and comprehensive global description of the spectrum of patients with ACS.
    Source
    Am J Cardiol. 2002 Aug 15;90(4):358-63.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47154
    PubMed ID
    12161222
    Related Resources
    Link to Article in PubMed
    Collections
    Population and Quantitative Health Sciences Publications

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