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    Usefulness of statin drugs in protecting against atrial fibrillation in patients with coronary artery disease

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    Authors
    Young-Xu, Yinong
    Jabbour, Samer
    Goldberg, Robert J.
    Blatt, Charles M.
    Graboys, Thomas B.
    Bilchik, Brian Z.
    Ravid, Shmuel
    UMass Chan Affiliations
    Department of Medicine, Division of Cardiovascular Medicine
    Document Type
    Journal Article
    Publication Date
    2003-12-17
    Keywords
    Aged
    Antilipemic Agents
    Atrial Fibrillation
    Cholesterol
    Chronic Disease
    Coronary Artery Disease
    Female
    Humans
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Incidence
    Longitudinal Studies
    Male
    Multivariate Analysis
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    United States
    Bioinformatics
    Biostatistics
    Epidemiology
    Health Services Research
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    Link to Full Text
    http://dx.doi.org/10.1016/j.amjcard.2003.08.040
    Abstract
    Atrial fibrillation (AF) is prevalent in the elderly, in patients with hypertension, and in patients with coronary artery disease (CAD). We hypothesized that statin therapy might be effective in preventing AF in patients with CAD and examined this hypothesis in a sample of patients with chronic stable CAD without AF, followed prospectively at a large outpatient cardiology practice. The association between statin use and the risk of developing AF was examined univariately and then with adjustment for potential confounding factors. Four hundred forty-nine men and women between the ages of 40 and 87 years were followed for an average of 5 years. Fifty-two patients (12%) developed AF during follow-up. Statin therapy was used by 59% of the patients during the study period and was associated with a significantly reduced risk of developing AF (crude odds ratio, 0.48, 95% confidence interval 0.28 to 0.83). This association remained significant after adjustment for potential confounders, including age, hypertension, left ventricular systolic function, occurrence of heart failure or acute ischemic events, and baseline cholesterol and changes in cholesterol levels (adjusted odds ratio 0.37, 95% confidence interval 0.18 to 0.76). Use of statins in patients with chronic stable CAD appears to be protective against AF. The underlying mechanism for this effect is unknown but appears to be independent of the reduction in serum cholesterol levels.
    Source
    Am J Cardiol. 2003 Dec 15;92(12):1379-83.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47170
    PubMed ID
    14675569
    Related Resources
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    Population and Quantitative Health Sciences Publications

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