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dc.contributor.authorFurman, Mark I.
dc.contributor.authorGore, Joel M.
dc.contributor.authorAnderson, Frederick A.
dc.contributor.authorBudaj, Andrzej
dc.contributor.authorGoodman, Shaun G.
dc.contributor.authorAvezum, Ávaro
dc.contributor.authorLópez-Sendón, José
dc.contributor.authorKlein, Werner
dc.contributor.authorMukherjee, Debabrata
dc.contributor.authorEagle, Kim A.
dc.contributor.authorDabbous, Omar H.
dc.contributor.authorGoldberg, Robert J.
dc.date2022-08-11T08:10:39.000
dc.date.accessioned2022-08-23T17:15:28Z
dc.date.available2022-08-23T17:15:28Z
dc.date.issued2004-01-24
dc.date.submitted2010-05-27
dc.identifier.citationAm Heart J. 2004 Jan;147(1):42-8.
dc.identifier.issn0002-8703 (Linking)
dc.identifier.pmid14691417
dc.identifier.urihttp://hdl.handle.net/20.500.14038/47174
dc.description.abstractOBJECTIVE: To examine the association between elevated leukocyte count and hospital mortality and heart failure in patients enrolled in the multinational, observational Global Registry of Acute Coronary Events (GRACE). BACKGROUND: Elevated leukocyte count is associated with adverse hospital outcomes in patients presenting with acute myocardial infarction (AMI). The association of this prognostic factor with hospital mortality and heart failure in patients with other acute coronary syndromes (ACS) is unclear. METHODS: We examined the association between admission leukocyte count and hospital mortality and heart failure in 8269 patients presenting with an ACS. This association was examined separately in patients with ST-segment elevation AMI, non-ST-segment elevation AMI, and unstable angina. Leukocyte count was divided into 4 mutually exclusive groups (Q): Q1 <6000, Q2 = 6000-9999, Q3 = 10,000-11,999, Q4 >12,000. Multiple logistic regression analysis was performed to examine the association between elevated leukocyte count and hospital events while accounting for the simultaneous effect of several potentially confounding variables. RESULTS: Increasing leukocyte count was significantly associated with hospital death (adjusted odds ratio [OR] 2.8, 95% CI 2.1-3.6 for Q4 compared to Q2 [normal range]) and heart failure (OR 2.7, 95% CI 2.2-3.4) for patients presenting with ACS. This association was seen in patients with ST-segment elevation AMI (OR for hospital death 3.2, 95% CI 2.1-4.7; OR for heart failure 2.4, 95% CI 1.8-3.3), non-ST-segment elevation AMI (OR for hospital death 1.9, 95% CI 1.2-3.0; OR for heart failure 1.7, 95% CI 1.1-2.5), or unstable angina (OR for hospital death 2.8, 95% CI 1.4-5.5; OR for heart failure 2.0, 95% CI 0.9-4.4). CONCLUSION: In men and women of all ages with the spectrum of ACS, initial leukocyte count is an independent predictor of hospital death and the development of heart failure.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=14691417&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.ahj.2003.07.003
dc.subjectAdult
dc.subjectAged
dc.subjectAnalysis of Variance
dc.subjectAngina, Unstable
dc.subjectArrhythmias, Cardiac
dc.subjectFemale
dc.subjectHeart Failure
dc.subject*Hospital Mortality
dc.subjectHumans
dc.subjectInflammation
dc.subject*Leukocyte Count
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMyocardial Infarction
dc.subjectPredictive Value of Tests
dc.subjectSyndrome
dc.subjectBiostatistics
dc.subjectCardiovascular Diseases
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.titleElevated leukocyte count and adverse hospital events in patients with acute coronary syndromes: findings from the Global Registry of Acute Coronary Events (GRACE)
dc.typeJournal Article
dc.source.journaltitleAmerican heart journal
dc.source.volume147
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/321
dc.identifier.contextkey1333074
html.description.abstract<p>OBJECTIVE: To examine the association between elevated leukocyte count and hospital mortality and heart failure in patients enrolled in the multinational, observational Global Registry of Acute Coronary Events (GRACE).</p> <p>BACKGROUND: Elevated leukocyte count is associated with adverse hospital outcomes in patients presenting with acute myocardial infarction (AMI). The association of this prognostic factor with hospital mortality and heart failure in patients with other acute coronary syndromes (ACS) is unclear.</p> <p>METHODS: We examined the association between admission leukocyte count and hospital mortality and heart failure in 8269 patients presenting with an ACS. This association was examined separately in patients with ST-segment elevation AMI, non-ST-segment elevation AMI, and unstable angina. Leukocyte count was divided into 4 mutually exclusive groups (Q): Q1 <6000, Q2 = 6000-9999, Q3 = 10,000-11,999, Q4 >12,000. Multiple logistic regression analysis was performed to examine the association between elevated leukocyte count and hospital events while accounting for the simultaneous effect of several potentially confounding variables. RESULTS: Increasing leukocyte count was significantly associated with hospital death (adjusted odds ratio [OR] 2.8, 95% CI 2.1-3.6 for Q4 compared to Q2 [normal range]) and heart failure (OR 2.7, 95% CI 2.2-3.4) for patients presenting with ACS. This association was seen in patients with ST-segment elevation AMI (OR for hospital death 3.2, 95% CI 2.1-4.7; OR for heart failure 2.4, 95% CI 1.8-3.3), non-ST-segment elevation AMI (OR for hospital death 1.9, 95% CI 1.2-3.0; OR for heart failure 1.7, 95% CI 1.1-2.5), or unstable angina (OR for hospital death 2.8, 95% CI 1.4-5.5; OR for heart failure 2.0, 95% CI 0.9-4.4).</p> <p>CONCLUSION: In men and women of all ages with the spectrum of ACS, initial leukocyte count is an independent predictor of hospital death and the development of heart failure.</p>
dc.identifier.submissionpathqhs_pp/321
dc.contributor.departmentDepartment of Surgery
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pages42-8


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