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dc.contributor.authorSpencer, Frederick A.
dc.contributor.authorEmery, Cathy
dc.contributor.authorLessard, Darleen M.
dc.contributor.authorGoldberg, Robert J.
dc.date2022-08-11T08:10:39.000
dc.date.accessioned2022-08-23T17:15:31Z
dc.date.available2022-08-23T17:15:31Z
dc.date.issued2007-08-07
dc.date.submitted2010-05-27
dc.identifier.citationAm J Med. 2007 Aug;120(8):678-84. <a href="http://dx.doi.org/10.1016/j.amjmed.2006.06.046">Link to article on publisher's site</a>
dc.identifier.issn0002-9343 (Linking)
dc.identifier.doi10.1016/j.amjmed.2006.06.046
dc.identifier.pmid17679126
dc.identifier.urihttp://hdl.handle.net/20.500.14038/47186
dc.description.abstractPURPOSE: The purpose of this study was to examine the magnitude, risk factors, management strategies, and outcomes in a population-based investigation of patients with upper, as compared with lower, extremity deep vein thrombosis diagnosed in 1999. METHODS: The medical records of all residents from Worcester, Massachusetts (2000 census=478,000) diagnosed with ICD-9 codes consistent with possible deep vein thrombosis at all Worcester hospitals during 1999 were reviewed and validated. RESULTS: The age-adjusted attack rate (per 100,000 population) of upper extremity deep vein thrombosis was 16 (95% confidence interval [CI], 13-20) compared with 91 (95% CI, 83-100) for lower extremity deep vein thrombosis. Patients with upper extremity deep vein thrombosis were significantly more likely to have undergone recent central line placement, a cardiac procedure, or an intensive care unit admission than patients with lower extremity deep vein thrombosis. Although short-term and 1-year recurrence rates of venous thromboembolism and all-cause mortality were not significantly different between patients with upper, versus lower, extremity deep vein thrombosis, patients with upper extremity deep vein thrombosis were less likely to have pulmonary embolism at presentation or in follow-up. CONCLUSIONS: Patients with upper extremity deep vein thrombosis represent a clinically important patient population in the community setting. Risk factors, occurrence of pulmonary embolism, and timing and location of venous thromboembolism recurrence differ between patients with upper as compared with lower extremity deep vein thrombosis. These data suggest that strategies for prophylaxis and treatment of upper extremity deep vein thrombosis need further study and refinement.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17679126&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.amjmed.2006.06.046
dc.subjectAged
dc.subjectCatheterization, Central Venous
dc.subjectFemale
dc.subjectHumans
dc.subjectIncidence
dc.subjectLower Extremity
dc.subjectMale
dc.subjectMassachusetts
dc.subjectMiddle Aged
dc.subjectMultivariate Analysis
dc.subjectPulmonary Embolism
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.subject*Upper Extremity
dc.subjectVenous Thrombosis
dc.subjectBioinformatics
dc.subjectBiostatistics
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.titleUpper extremity deep vein thrombosis: a community-based perspective
dc.typeJournal Article
dc.source.journaltitleThe American journal of medicine
dc.source.volume120
dc.source.issue8
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/332
dc.identifier.contextkey1333085
html.description.abstract<p>PURPOSE: The purpose of this study was to examine the magnitude, risk factors, management strategies, and outcomes in a population-based investigation of patients with upper, as compared with lower, extremity deep vein thrombosis diagnosed in 1999.</p> <p>METHODS: The medical records of all residents from Worcester, Massachusetts (2000 census=478,000) diagnosed with ICD-9 codes consistent with possible deep vein thrombosis at all Worcester hospitals during 1999 were reviewed and validated.</p> <p>RESULTS: The age-adjusted attack rate (per 100,000 population) of upper extremity deep vein thrombosis was 16 (95% confidence interval [CI], 13-20) compared with 91 (95% CI, 83-100) for lower extremity deep vein thrombosis. Patients with upper extremity deep vein thrombosis were significantly more likely to have undergone recent central line placement, a cardiac procedure, or an intensive care unit admission than patients with lower extremity deep vein thrombosis. Although short-term and 1-year recurrence rates of venous thromboembolism and all-cause mortality were not significantly different between patients with upper, versus lower, extremity deep vein thrombosis, patients with upper extremity deep vein thrombosis were less likely to have pulmonary embolism at presentation or in follow-up.</p> <p>CONCLUSIONS: Patients with upper extremity deep vein thrombosis represent a clinically important patient population in the community setting. Risk factors, occurrence of pulmonary embolism, and timing and location of venous thromboembolism recurrence differ between patients with upper as compared with lower extremity deep vein thrombosis. These data suggest that strategies for prophylaxis and treatment of upper extremity deep vein thrombosis need further study and refinement.</p>
dc.identifier.submissionpathqhs_pp/332
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pages678-84


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