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    Incident diabetes in relation to weight patterns during middle age

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    Authors
    Waring, Molly E.
    Eaton, Charles B.
    Lasater, Thomas M.
    Lapane, Kate L.
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2010-01-30
    Keywords
    Adult
    Body Mass Index
    Body Weight
    Cohort Studies
    Diabetes Mellitus, Type 2
    Female
    Humans
    Incidence
    Male
    Middle Aged
    Obesity
    Risk Factors
    Weight Gain
    Weight Loss
    Bioinformatics
    Biostatistics
    Epidemiology
    Health Services Research
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    Link to Full Text
    http://dx.doi.org/10.1093/aje/kwp433
    Abstract
    The authors examined the association between weight patterns during middle age and incident type 2 diabetes mellitus using a subset (n = 1,476) of the Framingham Heart Study original cohort limited-access data set (1948-2003). Participants diagnosed with diabetes before age 50 years were excluded. A functional principal components analysis of body mass index from age 40 years to age 50 years was used to define weight patterns in terms of overall weight status (normal weight, overweight, or obese), weight change (weight loss, stable weight, or weight gain), and weight cycling. Overall overweight and obesity were associated with higher rates of diabetes (for overall overweight, crude hazard ratio (HR) = 3.2, 95% confidence interval (CI): 2.3, 4.6; for overall obesity, crude HR = 8.8, 95% CI: 6.0, 12.8). Weight cycling was also associated with higher rates of diabetes (crude HR = 1.6, 95% CI: 1.2, 2.1). Neither weight loss nor weight gain was associated with incident diabetes. After adjustment for overall weight status, weight cycling was no longer associated with higher rates of diabetes. This study underscores the importance of obesity in diabetes risk and the importance of preventing the development of overweight and obesity earlier in life.
    Source
    Am J Epidemiol. 2010 Mar 1;171(5):550-6. Epub 2010 Jan 28. Link to article on publisher's site
    DOI
    10.1093/aje/kwp433
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47225
    PubMed ID
    20110286
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1093/aje/kwp433
    Scopus Count
    Collections
    Population and Quantitative Health Sciences Publications

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