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dc.contributor.authorMacNeil, A.
dc.contributor.authorSumba, Peter Odada
dc.contributor.authorLutzke, Mary L.
dc.contributor.authorMoormann, Ann M.
dc.contributor.authorRochford, Rosemary A.
dc.date2022-08-11T08:10:39.000
dc.date.accessioned2022-08-23T17:15:45Z
dc.date.available2022-08-23T17:15:45Z
dc.date.issued2003-05-29
dc.date.submitted2010-06-08
dc.identifier.citationBr J Cancer. 2003 May 19;88(10):1566-9. <a href="http://dx.doi.org/10.1038/sj.bjc.6600929">Link to article on publisher's site</a>
dc.identifier.issn0007-0920 (Linking)
dc.identifier.doi10.1038/sj.bjc.6600929
dc.identifier.pmid12771923
dc.identifier.urihttp://hdl.handle.net/20.500.14038/47240
dc.description.abstractExposure to the plant Euphorbia tirucalli has been proposed to be a cofactor in the genesis of endemic Burkitt's lymphoma (eBL). The purpose of this study was to examine the effects of unpurified E. tirucalli latex on Epstein-Barr virus (EBV) gene expression. A Burkitt lymphoma cell line was treated with varying dilutions of the latex and the effects on EBV gene expression were measured. We observed that the latex was capable of reactivating the EBV lytic cycle in a dose-dependent manner and at dilutions as low as 10(-6). Simultaneous treatment of cells with E. tirucalli latex and the protein kinase C inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride blocked lytic cycle activation. These data suggest that environmental exposure to the latex of E. tirucalli could directly activate the EBV lytic cycle and provide further evidence of a role for E. tirucalli in the aetiology of eBL.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=12771923&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/sj.bjc.6600929
dc.subjectBurkitt Lymphoma
dc.subject*Environmental Exposure
dc.subjectEuphorbia
dc.subjectGene Expression Regulation
dc.subjectHerpesvirus 4, Human
dc.subjectHumans
dc.subjectLatex
dc.subjectTumor Cells, Cultured
dc.subjectBiostatistics
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.subjectImmunology and Infectious Disease
dc.titleActivation of the Epstein-Barr virus lytic cycle by the latex of the plant Euphorbia tirucalli
dc.typeJournal Article
dc.source.journaltitleBritish journal of cancer
dc.source.volume88
dc.source.issue10
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/384
dc.identifier.contextkey1347915
html.description.abstract<p>Exposure to the plant Euphorbia tirucalli has been proposed to be a cofactor in the genesis of endemic Burkitt's lymphoma (eBL). The purpose of this study was to examine the effects of unpurified E. tirucalli latex on Epstein-Barr virus (EBV) gene expression. A Burkitt lymphoma cell line was treated with varying dilutions of the latex and the effects on EBV gene expression were measured. We observed that the latex was capable of reactivating the EBV lytic cycle in a dose-dependent manner and at dilutions as low as 10(-6). Simultaneous treatment of cells with E. tirucalli latex and the protein kinase C inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride blocked lytic cycle activation. These data suggest that environmental exposure to the latex of E. tirucalli could directly activate the EBV lytic cycle and provide further evidence of a role for E. tirucalli in the aetiology of eBL.</p>
dc.identifier.submissionpathqhs_pp/384
dc.contributor.departmentDepartment of Pediatrics
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages1566-9


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