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    Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya

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    Authors
    Moormann, Ann M.
    Embury, Paula E.
    Opondo, J.
    Sumba, Peter Odada
    Ouma, J. H.
    Kazura, James W.
    John, Chandy C.
    UMass Chan Affiliations
    Department of Pediatrics
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2004-08-17
    Keywords
    Adolescent
    Adult
    Aged
    Altitude
    Child
    Child, Preschool
    Endemic Diseases
    Glucosephosphate Dehydrogenase Deficiency
    Hemoglobin, Sickle
    Humans
    Infant
    Infant, Newborn
    Kenya
    Malaria, Falciparum
    Middle Aged
    Polymorphism, Genetic
    Prevalence
    Residence Characteristics
    Sickle Cell Trait
    Biostatistics
    Epidemiology
    Health Services Research
    Immunology and Infectious Disease
    Pediatrics
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    Link to Full Text
    http://dx.doi.org/10.1016/S0035-9203(03)80010-X
    Abstract
    Sickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1% in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.
    Source
    Trans R Soc Trop Med Hyg. 2003 Sep-Oct;97(5):513-4. Link to article on publisher's site
    DOI
    10.1016/S0035-9203(03)80010-X
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47241
    PubMed ID
    15307413
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0035-9203(03)80010-X
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    Population and Quantitative Health Sciences Publications

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