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Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya

dc.contributor.authorMoormann, Ann M.
dc.contributor.authorEmbury, Paula E.
dc.contributor.authorOpondo, J.
dc.contributor.authorSumba, Peter Odada
dc.contributor.authorOuma, J. H.
dc.contributor.authorKazura, James W.
dc.contributor.authorJohn, Chandy C.
dc.date2022-08-11T08:10:39.000
dc.date.accessioned2022-08-23T17:15:46Z
dc.date.available2022-08-23T17:15:46Z
dc.date.issued2004-08-17
dc.date.submitted2010-06-08
dc.identifier.citationTrans R Soc Trop Med Hyg. 2003 Sep-Oct;97(5):513-4. <a href="http://dx.doi.org/10.1016/S0035-9203(03)80010-X">Link to article on publisher's site</a>
dc.identifier.issn0035-9203 (Linking)
dc.identifier.doi10.1016/S0035-9203(03)80010-X
dc.identifier.pmid15307413
dc.identifier.urihttp://hdl.handle.net/20.500.14038/47241
dc.description.abstractSickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1% in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15307413&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/S0035-9203(03)80010-X
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAltitude
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectEndemic Diseases
dc.subjectGlucosephosphate Dehydrogenase Deficiency
dc.subjectHemoglobin, Sickle
dc.subjectHumans
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectKenya
dc.subjectMalaria, Falciparum
dc.subjectMiddle Aged
dc.subjectPolymorphism, Genetic
dc.subjectPrevalence
dc.subjectResidence Characteristics
dc.subjectSickle Cell Trait
dc.subjectBiostatistics
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.subjectImmunology and Infectious Disease
dc.subjectPediatrics
dc.titleFrequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya
dc.typeJournal Article
dc.source.journaltitleTransactions of the Royal Society of Tropical Medicine and Hygiene
dc.source.volume97
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/385
dc.identifier.contextkey1347916
html.description.abstract<p>Sickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1% in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.</p>
dc.identifier.submissionpathqhs_pp/385
dc.contributor.departmentDepartment of Pediatrics
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages513-4


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