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    Exposure to holoendemic malaria results in elevated Epstein-Barr virus loads in children

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    Authors
    Moormann, Ann M.
    Chelimo, Kiprotich
    Sumba, Peter Odada
    Lutzke, Mary L.
    Ploutz-Snyder, Robert
    Newton, Duane
    Kazura, James W.
    Rochford, Rosemary A.
    UMass Chan Affiliations
    Department of Pediatrics
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2005-03-19
    Keywords
    Adolescent
    Adult
    Age Distribution
    Child
    Child, Preschool
    Epstein-Barr Virus Infections
    Herpesvirus 4, Human
    Humans
    Infant
    Kenya
    Malaria
    United States
    *Viral Load
    Biostatistics
    Epidemiology
    Health Services Research
    Immunology and Infectious Disease
    Pediatrics
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    Abstract
    Perennial and intense malaria transmission (holoendemic malaria) and Epstein-Barr virus (EBV) infection are 2 cofactors in the pathogenesis of endemic Burkitt lymphoma (eBL). In the present study, we compared EBV loads in children living in 2 regions of Kenya with differing malaria transmission intensities: Kisumu District, where malaria transmission is holoendemic, and Nandi District, where malaria transmission is sporadic. For comparison, blood samples were also obtained from US adults, Kenyan adults, and patients with eBL. Extraction of DNA from blood and quantification by polymerase chain reaction give an EBV load estimate that reflects the number of EBV-infected B cells. We observed a significant linear trend in mean EBV load, with the lowest EBV load detected in US adults and increasing EBV loads detected in Kenyan adults, Nandi children, Kisumu children, and patients with eBL, respectively. In addition, EBV loads were significantly higher in Kisumu children 1-4 years of age than in Nandi children of the same age. Our results support the hypothesis that repeated malaria infections in very young children modulate the persistence of EBV and increase the risk for the development of eBL.
    Source
    J Infect Dis. 2005 Apr 15;191(8):1233-8. Epub 2005 Mar 9. Link to article on publisher's site
    DOI
    10.1086/428910
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/47247
    PubMed ID
    15776368
    Related Resources

    Link to Article in PubMed

    Rights
    © 2005 by the Infectious Diseases Society of America.
    ae974a485f413a2113503eed53cd6c53
    10.1086/428910
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    Population and Quantitative Health Sciences Publications

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