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Exposure to holoendemic malaria results in elevated Epstein-Barr virus loads in children

dc.contributor.authorMoormann, Ann M.
dc.contributor.authorChelimo, Kiprotich
dc.contributor.authorSumba, Peter Odada
dc.contributor.authorLutzke, Mary L.
dc.contributor.authorPloutz-Snyder, Robert
dc.contributor.authorNewton, Duane
dc.contributor.authorKazura, James W.
dc.contributor.authorRochford, Rosemary A.
dc.date2022-08-11T08:10:39.000
dc.date.accessioned2022-08-23T17:15:47Z
dc.date.available2022-08-23T17:15:47Z
dc.date.issued2005-03-19
dc.date.submitted2010-06-08
dc.identifier.citationJ Infect Dis. 2005 Apr 15;191(8):1233-8. Epub 2005 Mar 9. <a href="http://dx.doi.org/10.1086/428910">Link to article on publisher's site</a>
dc.identifier.issn0022-1899 (Linking)
dc.identifier.doi10.1086/428910
dc.identifier.pmid15776368
dc.identifier.urihttp://hdl.handle.net/20.500.14038/47247
dc.description.abstractPerennial and intense malaria transmission (holoendemic malaria) and Epstein-Barr virus (EBV) infection are 2 cofactors in the pathogenesis of endemic Burkitt lymphoma (eBL). In the present study, we compared EBV loads in children living in 2 regions of Kenya with differing malaria transmission intensities: Kisumu District, where malaria transmission is holoendemic, and Nandi District, where malaria transmission is sporadic. For comparison, blood samples were also obtained from US adults, Kenyan adults, and patients with eBL. Extraction of DNA from blood and quantification by polymerase chain reaction give an EBV load estimate that reflects the number of EBV-infected B cells. We observed a significant linear trend in mean EBV load, with the lowest EBV load detected in US adults and increasing EBV loads detected in Kenyan adults, Nandi children, Kisumu children, and patients with eBL, respectively. In addition, EBV loads were significantly higher in Kisumu children 1-4 years of age than in Nandi children of the same age. Our results support the hypothesis that repeated malaria infections in very young children modulate the persistence of EBV and increase the risk for the development of eBL.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15776368&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rights© 2005 by the Infectious Diseases Society of America.
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAge Distribution
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectEpstein-Barr Virus Infections
dc.subjectHerpesvirus 4, Human
dc.subjectHumans
dc.subjectInfant
dc.subjectKenya
dc.subjectMalaria
dc.subjectUnited States
dc.subject*Viral Load
dc.subjectBiostatistics
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.subjectImmunology and Infectious Disease
dc.subjectPediatrics
dc.titleExposure to holoendemic malaria results in elevated Epstein-Barr virus loads in children
dc.typeJournal Article
dc.source.journaltitleThe Journal of infectious diseases
dc.source.volume191
dc.source.issue8
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1390&amp;context=qhs_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/qhs_pp/390
dc.identifier.contextkey1347921
refterms.dateFOA2022-08-23T17:15:47Z
html.description.abstract<p>Perennial and intense malaria transmission (holoendemic malaria) and Epstein-Barr virus (EBV) infection are 2 cofactors in the pathogenesis of endemic Burkitt lymphoma (eBL). In the present study, we compared EBV loads in children living in 2 regions of Kenya with differing malaria transmission intensities: Kisumu District, where malaria transmission is holoendemic, and Nandi District, where malaria transmission is sporadic. For comparison, blood samples were also obtained from US adults, Kenyan adults, and patients with eBL. Extraction of DNA from blood and quantification by polymerase chain reaction give an EBV load estimate that reflects the number of EBV-infected B cells. We observed a significant linear trend in mean EBV load, with the lowest EBV load detected in US adults and increasing EBV loads detected in Kenyan adults, Nandi children, Kisumu children, and patients with eBL, respectively. In addition, EBV loads were significantly higher in Kisumu children 1-4 years of age than in Nandi children of the same age. Our results support the hypothesis that repeated malaria infections in very young children modulate the persistence of EBV and increase the risk for the development of eBL.</p>
dc.identifier.submissionpathqhs_pp/390
dc.contributor.departmentDepartment of Pediatrics
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages1233-8


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